BDBM50550263 CHEMBL4748750
SMILES C[C@@H]1CN(CCN1c1nccc(n1)C(=O)NC1C2CC3CC1CC(O)(C3)C2)c1ccc(cc1F)S(C)(=O)=O
InChI Key InChIKey=SSKKTEYBWOVEET-REKAHOPZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50550263
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using cortisone in presence of NADPH regenerating-system incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sk Chemicals
Curated by ChEMBL
Sk Chemicals
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole-cell patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in pooled human liver microsomes using diclofenac as substrate in presence of NADPH incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 in pooled human liver microsomes using mephenytoin as substrate in presence of NADPH incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in pooled human liver microsomes using dextromethorphan as substrate in presence of NADPH incubated for 10 mins by LC-MS/MS anal...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in pooled human liver microsomes using midazolam as substrate in presence of NADPH incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human 11beta-HSD1 expressed in microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in microsomesMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Sk Chemicals
Curated by ChEMBL
Sk Chemicals
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human 11beta-HSD2 expressed in microsomesMore data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at glucocorticoid receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+3nMAssay Description:Antagonist activity at glucocorticoid receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at mineralocorticoid receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+3nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of UGT1A1 (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Sk Chemicals
Curated by ChEMBL
Sk Chemicals
Curated by ChEMBL
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 in pooled human liver microsomes using phenacetin as substrate in presence of NADPH incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair