BDBM50552392 CHEMBL4743779

SMILES Cc1ccc(C)c(Cn2c(nc3ccc(cc23)-c2cnn(C)c2)C(O)c2ccncc2)c1

InChI Key InChIKey=RZGFWGNCSYUEPR-UHFFFAOYSA-N

Data  2 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50552392   

TargetTumor necrosis factor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50552392(CHEMBL4743779)
Affinity DataKd:  13nMAssay Description:Binding affinity to human TNF measured after 2 hrs by surface plasmon resonanceMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50552392(CHEMBL4743779)
Affinity DataIC50:  202nMAssay Description:Inhibition of exogenous human TNFalpha in HEK-Blue-CD40L cells assessed as reduction in TNF-alpha-induced NFkappaB activation incubated for 18 hrs by...More data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50552392(CHEMBL4743779)
Affinity DataKd:  13nMAssay Description:Binding affinity to human TNF-alpha assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Mus musculus)TBA
LigandPNGBDBM50552392(CHEMBL4743779)
Affinity DataIC50:  125nMAssay Description:Antagonist activity at adrenergic Alpha-1D receptor in rat aortaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50552392(CHEMBL4743779)
Affinity DataKd:  13nMAssay Description:Antagonist activity at adrenergic Alpha-1D receptor in rat aortaMore data for this Ligand-Target Pair