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Found 5 Enz. Inhib. hit(s) with Target = 'Tumor necrosis factor' and Ligand = 'BDBM50552392'
TargetTumor necrosis factor(Mus musculus)TBA
LigandPNGBDBM50552392(CHEMBL4743779)
Affinity DataIC50:  125nMAssay Description:Antagonist activity at adrenergic Alpha-1D receptor in rat aortaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552392(CHEMBL4743779)
Affinity DataIC50:  202nMAssay Description:Inhibition of exogenous human TNFalpha in HEK-Blue-CD40L cells assessed as reduction in TNF-alpha-induced NFkappaB activation incubated for 18 hrs by...More data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552392(CHEMBL4743779)
Affinity DataKd:  13nMAssay Description:Binding affinity to human TNF-alpha assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552392(CHEMBL4743779)
Affinity DataKd:  13nMAssay Description:Binding affinity to human TNF measured after 2 hrs by surface plasmon resonanceMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552392(CHEMBL4743779)
Affinity DataKd:  13nMAssay Description:Antagonist activity at adrenergic Alpha-1D receptor in rat aortaMore data for this Ligand-Target Pair