BDBM50553436 CHEMBL4744041
SMILES CC(C)OC1CN(C1)C(=O)NCc1ccc(cc1C)-c1ccnc(Nc2cnn(C)c2)n1
InChI Key InChIKey=BMWMKGNVAMXXCH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 29 hits for monomerid = 50553436
Affinity DataKi: 5.00E+4nMAssay Description:Time-dependent inhibition of CYP3A4 in human liver microsomes using testosterone in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CD69 in human whole blood preincubated for 30 mins followed by anti-human IgD stimulation and measured after 18 to 22 hrs by flow cytom...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in BTK phosphorylation measured after 30 mins by phosphotyrosine detection methodMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKd: 430nMAssay Description:Binding affinity to human wild-type AAK1 (G25 to L333 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataKd: 1.10E+3nMAssay Description:Binding affinity to human wild-type BMP2K (S34 to N329 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataKd: 420nMAssay Description:Binding affinity to wild-type human partial length CDKL2 (M1 to D327 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataKd: 460nMAssay Description:Binding affinity to wild-type human partial length JAK2 JH1 catalytic domain (A829 to G1132 residues) expressed in mammalian expression system by Kin...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-phosphate 5-kinase type-1 alpha(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to wild-type human full length PIP5K1A (M1 to H562 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataKd: 1.20E+3nMAssay Description:Binding affinity to wild-type human full length RIOK1 (M1 to K568 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataKd: 2.40E+3nMAssay Description:Binding affinity to wild-type human partial length RIOK2 (M1 to D313 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataKd: 0.300nMAssay Description:Binding affinity to wild-type human full length BTK (M1 to S659 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of BTK in human Ramos cells assessed as reduction in BCR mediated PLCgamma2 phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in anti-IgD-induced B cell activation preincubated for 30 mins followed by rabbit F(ab')2 anti-...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in goat F(ab')2 anti-human IgM antibody-induced B cell activation measured after 3 days by cell...More data for this Ligand-Target Pair
Affinity DataIC50: 2.65E+4nMAssay Description:Antagonist activity at human H2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate measured after 15 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate measured after 15 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate measured after 30 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate measured after 15 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate measured after 15 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 15 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human ERG by automated patch-clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibition of BTK in human whole blood derived neutrophils assessed as reduction in SLE IC/FcgammaR-induced ROS generation preincubated for 30 mins f...More data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:Inhibition of BTK in human PBMC assessed as suppression of TNFalpha/FcgammaR-induced monocyte activation by measuring reduction in cytokine productio...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of BTK in DBA1 mouse whole blood assessed as reduction in BTK phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human BTK using fluorescein-labeled polyGAT peptide as substrate incubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of BTK phosphorylation in human whole blood assessed as reduction in BTK phosphorylation incubated for 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged BTK expressed in baculovirus infected Sf21 insect cells using fluorescein-labeled ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 19(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataKd: 130nMAssay Description:Binding affinity to wild-type human partial length YSK4 (T1019 to H1328 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair