BDBM50572933 CHEMBL4861379

SMILES NS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2ccc(F)c(c2)-c2ccc(Sc3nn[nH]c3C(O)=O)cc2)-c2nc(cs2)C(O)=O)cc1F

InChI Key InChIKey=FTXMYFXODHSEMB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50572933   

Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572933(CHEMBL4861379)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Mus musculus (Mouse))
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572933(CHEMBL4861379)
Affinity DataIC50:  230nMAssay Description:Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Mus musculus (Mouse))
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572933(CHEMBL4861379)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572933(CHEMBL4861379)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed