BDBM50606310 CHEMBL5169427::US20230286979, Isomer 2 of Example 1::US20230321108, Isomer 2 of Example 1
SMILES [H][C@@]12C[C@]1([H])N(CCN2C(=O)[C@H](CNC(C)C)c1ccc(Cl)cc1)c1ncnc2NC(=O)C[C@@H](C)c12
InChI Key InChIKey=RXNPEQZHMGFNAY-GEALJGNFSA-N
Data 17 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50606310
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 0.350nMAssay Description:Envision model plate reader (Molecular Devices)White 384-well plate (Thermo, Art. No. #264706)Main reagents included in an HTRF kinEASE TK kit (Cisbi...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Nanjing Chia-Tai Tianqing Pharmaceutical
Curated by ChEMBL
Nanjing Chia-Tai Tianqing Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.52E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes at 0.01 to 30 uM using phenacetin as substrate in presence of NADPH by UPLC-MS/MS analysisMore data for this Ligand-Target Pair
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 0.0900nMAssay Description:Envision model plate reader (Molecular Devices)White 384-well plate (Thermo, Art. No. #264706)Main reagents included in an HTRF kinEASE TK kit (Cisbi...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 0.350nMAssay Description:After all the reagents were prepared according to the above method, except for the enzyme, the reagents were equilibrated to the room temperature and...More data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 6.30nMAssay Description:After all the reagents were prepared according to the above method, except for the enzyme, the reagents were equilibrated to the room temperature and...More data for this Ligand-Target Pair
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 0.0900nMAssay Description:After all the reagents were prepared according to the above method, except for the enzyme, the reagents were equilibrated to the room temperature and...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 0.350nMAssay Description:a) first, a compound stock solution (10 mM DMSO solution) was diluted with DMSO to obtain a 100 µM compound solution, the compound solution was dilut...More data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 6.30nMAssay Description:a) first, a compound stock solution (10 mM DMSO solution) was diluted with DMSO to obtain a 100 µM compound solution, the compound solution was dilut...More data for this Ligand-Target Pair
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 0.0900nMAssay Description:a) first, a compound stock solution (10 mM DMSO solution) was diluted with DMSO to obtain a 100 µM compound solution, the compound solution was dilut...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Nanjing Chia-Tai Tianqing Pharmaceutical
Curated by ChEMBL
Nanjing Chia-Tai Tianqing Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 2.06E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes at 0.01 to 30 uM using dextromethorphan as substrate in presence of NADPH by UPLC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
Nanjing Chia-Tai Tianqing Pharmaceutical
Curated by ChEMBL
Nanjing Chia-Tai Tianqing Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes at 0.01 to 30 uM using mephenytoin as substrate in presence of NADPH by UPLC-MS/MS analysisMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant AKT1 (104 to 480 end residues) (unknown origin) catalytic domain expressed in Sf21 cells using peptide substrate incubated ...More data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 6.30nMAssay Description:Inhibition of recombinant AKT2 (120 to 481 end residues) (unknown origin) catalytic domain expressed in Sf21 cells using peptide substrate incubated ...More data for this Ligand-Target Pair
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant N-terminal GST tagged AKT2 (108 to 479 end residues) (unknown origin) catalytic domain expressed in Sf21 cells using peptid...More data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Nanjing Chia-Tai Tianqing Pharmaceutical
Curated by ChEMBL
Nanjing Chia-Tai Tianqing Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes at 0.01 to 30 uM using phenacetin as substrate in presence of NADPH by UPLC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Nanjing Chia-Tai Tianqing Pharmaceutical
Curated by ChEMBL
Nanjing Chia-Tai Tianqing Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes at 0.01 to 30 uM using diclofenac as substrate in presence of NADPH by UPLC-MS/MS analysisMore data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 6.30nMAssay Description:Envision model plate reader (Molecular Devices)White 384-well plate (Thermo, Art. No. #264706)Main reagents included in an HTRF kinEASE TK kit (Cisbi...More data for this Ligand-Target Pair