BDBM514517 8-(7-chloroimidazo[1,5- a]pyridin-5-yl)-1,3,8- triazaspiro[4.5]decane-2,4- dione::US11096930, Example 3

SMILES Clc1cc(N2CCC3(CC2)NC(=O)NC3=O)n2cncc2c1

InChI Key InChIKey=LRFRCHCWYJRLJU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 514517   

TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514517(8-(7-chloroimidazo[1,5- a]pyridin-5-yl)-1,3,8- tri...)
Affinity DataIC50:  1.41E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton™ X100, 20 mM ascorbate, 10 μM methylen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514517(8-(7-chloroimidazo[1,5- a]pyridin-5-yl)-1,3,8- tri...)
Affinity DataIC50:  282nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton™ X100, 20 mM ascorbate, 10 μM methylen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent