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Found
1
Enz. Inhib. hit(s) with Target = 'Tryptophan 2,3-dioxygenase' and Ligand = 'BDBM514517'
Target
Tryptophan 2,3-dioxygenase
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM514517
(8-(7-chloroimidazo[1,5- a]pyridin-5-yl)-1,3,8- tri...)
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Affinity Data
IC50: 1.41E+3nM
Assay Description:
Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton™ X100, 20 mM ascorbate, 10 μM methylen...
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Target Info
PDB
Reactome pathway
KEGG
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Ligand Info
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In Depth
Details
US Patent
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