BDBM515907 2-(5-Chloro-2-ethyl-3- ((5-methoxy-3,4-dihydro- 2(1H)-isoquinolinyl) carbonyl)-7-methyl-1H- indol-1-yl)-N-methyl- N-(1-(2-propenoyl)-3- azetidinyl)acetamide::US11053226, Example 4-2

SMILES CCc1c(C(=O)N2CCc3c(C2)cccc3OC)c2cc(Cl)cc(C)c2n1CC(=O)N(C)C1CN(C1)C(=O)C=C

InChI Key InChIKey=DFJZGECTEKEWTM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 515907   

TargetGTPase KRas [1-169,G12C,C118A](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM515907(2-(5-Chloro-2-ethyl-3- ((5-methoxy-3,4-dihydro- 2(...)
Affinity DataIC50:  150nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent