BDBM519706 US11142525, Example 107

SMILES CC(C)n1cnnc1-c1cccc(n1)N1Cc2c(cc(nc2CN)N2CCC[C@H]2C)C1=O

InChI Key InChIKey=NZWZWDKHYUREIF-OAHLLOKOSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 519706   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM519706(US11142525, Example 107)
Affinity DataKi:  0.0400nMAssay Description:HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay (MSA). The reactions were conducted in 50 μL volumes in 96-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM519706(US11142525, Example 107)
Affinity DataKi:  0.0400nMAssay Description:Inhibition of HPK1 (unknown origin) assessed as inhibition constant in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM519706(US11142525, Example 107)
Affinity DataIC50:  22nMAssay Description:Inhibition of HPK1 (unknown origin) assessed as inhibition of SLP76 phosphorylation by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed