BDBM522421 8-fluoro-2-[trans-3- fluroocyclopentyl]-1- [(2R,4R)-2-methyl- tetrahydro-2H-pyran-4-yl]- 1H-imidazo[-c]quinoline, DIAST 13::US11161844, Example 37::US11161844, Example 38::US11161844, Example 43

SMILES C[C@@H]1C[C@@H](CCO1)n1c(nc2cnc3ccc(F)cc3c12)C1CCC(F)C1

InChI Key InChIKey=BYBVLCDFEBESJW-UWLZSVRSSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 522421   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522421(8-fluoro-2-[trans-3- fluroocyclopentyl]-1- [(2R,4R...)
Affinity DataIC50:  200nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522421(8-fluoro-2-[trans-3- fluroocyclopentyl]-1- [(2R,4R...)
Affinity DataIC50:  5.68nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM522421(8-fluoro-2-[trans-3- fluroocyclopentyl]-1- [(2R,4R...)
Affinity DataIC50:  202nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent