BDBM543481 US11279703, TABLE 6.351::US11279703, TABLE 6.353::US11279703, Table 1.4

SMILES CC(C)(C)S(=O)(=O)Nc1cc(ccc1F)-n1ccc2cnc(Nc3ccc(N4CCNCC4)c(F)c3)nc12

InChI Key InChIKey=UMNXPJRZMXUVHS-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 543481   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543481(US11279703, TABLE 6.351 | US11279703, TABLE 6.353 ...)
Affinity DataIC50:  6nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543481(US11279703, TABLE 6.351 | US11279703, TABLE 6.353 ...)
Affinity DataIC50:  60nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543481(US11279703, TABLE 6.351 | US11279703, TABLE 6.353 ...)
Affinity DataIC50:  33nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543481(US11279703, TABLE 6.351 | US11279703, TABLE 6.353 ...)
Affinity DataIC50:  64nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [91-163](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543481(US11279703, TABLE 6.351 | US11279703, TABLE 6.353 ...)
Affinity DataIC50:  216nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543481(US11279703, TABLE 6.351 | US11279703, TABLE 6.353 ...)
Affinity DataIC50:  76nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain testis-specific protein [22-138](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543481(US11279703, TABLE 6.351 | US11279703, TABLE 6.353 ...)
Affinity DataIC50:  118nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543481(US11279703, TABLE 6.351 | US11279703, TABLE 6.353 ...)
Affinity DataIC50:  2.10E+3nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543481(US11279703, TABLE 6.351 | US11279703, TABLE 6.353 ...)
Affinity DataIC50:  272nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543481(US11279703, TABLE 6.351 | US11279703, TABLE 6.353 ...)
Affinity DataIC50:  125nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 3 [51-123](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543481(US11279703, TABLE 6.351 | US11279703, TABLE 6.353 ...)
Affinity DataIC50:  59nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent