BDBM543649 US11279703, TABLE 6.238

SMILES COc1cc(Nc2ncc3ccn(-c4cccc(NS(=O)(=O)C(C)(C)C)c4)c3n2)ccc1N1CCN(C)CC1

InChI Key InChIKey=CFAMWQQPZPMCBQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 543649   

TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543649(US11279703, TABLE 6.238)
Affinity DataIC50:  431nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543649(US11279703, TABLE 6.238)
Affinity DataIC50:  5.20nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543649(US11279703, TABLE 6.238)
Affinity DataIC50:  130nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543649(US11279703, TABLE 6.238)
Affinity DataIC50:  82nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 3 [51-123](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543649(US11279703, TABLE 6.238)
Affinity DataIC50:  161nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain testis-specific protein [22-138](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543649(US11279703, TABLE 6.238)
Affinity DataIC50:  363nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543649(US11279703, TABLE 6.238)
Affinity DataIC50:  293nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [91-163](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543649(US11279703, TABLE 6.238)
Affinity DataIC50:  743nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent