BDBM543789 US11279703, TABLE 6.379::US11279703, TABLE 6.380

SMILES CNC1CCN(CC1)c1ccc(Nc2ncc3ccn(-c4ccc(F)c(NS(=O)(=O)C(C)(C)C)c4)c3n2)cc1F

InChI Key InChIKey=ZWICUQCQHFEFGL-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 543789   

TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543789(US11279703, TABLE 6.379 | US11279703, TABLE 6.380)
Affinity DataIC50:  123nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543789(US11279703, TABLE 6.379 | US11279703, TABLE 6.380)
Affinity DataIC50:  608nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543789(US11279703, TABLE 6.379 | US11279703, TABLE 6.380)
Affinity DataIC50:  86nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [91-163](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543789(US11279703, TABLE 6.379 | US11279703, TABLE 6.380)
Affinity DataIC50:  360nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 3 [51-123](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543789(US11279703, TABLE 6.379 | US11279703, TABLE 6.380)
Affinity DataIC50:  97nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain testis-specific protein [22-138](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543789(US11279703, TABLE 6.379 | US11279703, TABLE 6.380)
Affinity DataIC50:  185nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543789(US11279703, TABLE 6.379 | US11279703, TABLE 6.380)
Affinity DataIC50:  1.50E+3nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543789(US11279703, TABLE 6.379 | US11279703, TABLE 6.380)
Affinity DataIC50:  173nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543789(US11279703, TABLE 6.379 | US11279703, TABLE 6.380)
Affinity DataIC50:  150nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543789(US11279703, TABLE 6.379 | US11279703, TABLE 6.380)
Affinity DataIC50:  52nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543789(US11279703, TABLE 6.379 | US11279703, TABLE 6.380)
Affinity DataIC50:  88nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [91-163](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543789(US11279703, TABLE 6.379 | US11279703, TABLE 6.380)
Affinity DataIC50:  420nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain testis-specific protein [22-138](Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543789(US11279703, TABLE 6.379 | US11279703, TABLE 6.380)
Affinity DataIC50:  302nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543789(US11279703, TABLE 6.379 | US11279703, TABLE 6.380)
Affinity DataIC50:  9.90E+3nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Aptose Biosciences

US Patent
LigandPNGBDBM543789(US11279703, TABLE 6.379 | US11279703, TABLE 6.380)
Affinity DataIC50:  39nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent