BDBM544886 US11286268, Compound 369

SMILES COc1c(CN(C)C)cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N

InChI Key InChIKey=WBFYSYOBQUFCHW-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 544886   

TargetEukaryotic translation initiation factor 4E-binding protein 1(Homo sapiens (Human))
eFFECTOR Therapeutics, Inc.

US Patent
LigandPNGBDBM544886(US11286268, Compound 369)
Show SMILES COc1c(CN(C)C)cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N
Show InChI InChI=1S/C31H28ClN5O5S/c1-16-10-21(29-27(34-16)23(15-43-29)31(39)40)20-12-19(32)6-7-25(20)42-9-8-37-17(2)35-24-11-18(14-36(3)4)28(41-5)22(13-33)26(24)30(37)38/h6-7,10-12,15H,8-9,14H2,1-5H3,(H,39,40)
Affinity DataIC50: 1.32nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid