BDBM598581 N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-6-methylpyrimidin-4-yl)-1H-indazol-5-amine::US11613531, Example 211

SMILES Cc1cc(Nc2ccc3[nH]ncc3c2)nc(n1)N1CC2CC1CN2

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 598581   

TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598581(N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-6-methyl...)
Affinity DataIC50:  2.90nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598581(N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-6-methyl...)
Affinity DataIC50:  0.900nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent