BDBM598649 6-((1H-indazol-5-yl)amino)-2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-fluoropyrimidin-4-ol::US11613531, Example 320

SMILES Oc1nc(nc(Nc2ccc3[nH]ncc3c2)c1F)N1C2CCC1CNC2

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 598649   

TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598649(6-((1H-indazol-5-yl)amino)-2-(3,8-diazabicyclo[3.2...)
Affinity DataIC50:  8.70nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598649(6-((1H-indazol-5-yl)amino)-2-(3,8-diazabicyclo[3.2...)
Affinity DataIC50:  18nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent