BDBM605530 N-((1R,3S)-3-((5-chloro-4-(7-fluoro-3-isopropyl-2-methyl- 2H-indazol-5-yl)pyridin-2-yl)carbamoyl)-cyclohexyl)-4- methylpiperazine-1-carboxamide::US11673893, Example 8

SMILES CC(C)c1n(C)nc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)N2CCN(C)CC2)ncc1Cl

InChI Key InChIKey=OKLIXNGBJODOLI-AZUAARDMSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 605530   

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM605530(N-((1R,3S)-3-((5-chloro-4-(7-fluoro-3-isopropyl-2-...)
Affinity DataIC50:  63nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK9/Cyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM605530(N-((1R,3S)-3-((5-chloro-4-(7-fluoro-3-isopropyl-2-...)
Affinity DataIC50:  0.980nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK4/Cyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM605530(N-((1R,3S)-3-((5-chloro-4-(7-fluoro-3-isopropyl-2-...)
Affinity DataIC50:  38nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK2/Cyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent