BDBM60812 BDBM86641::US9173884, BC11-28

SMILES Cc1ccccc1Nc1ncnc2n(cc(-c3ccccc3)c12)-c1ccc(F)cc1

InChI Key InChIKey=KCNWFXKVXRZIGO-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 60812   

TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Boston College

LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50:  110nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Boston College

LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at mu opioid receptor in Hartley guinea pig ileum myenteric plexus longitudinal muscle assessed as effect on endomorphin 2-induce...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Rattus norvegicus)
Boston College

LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Boston College

LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP specific phosphodiesterase variant PDE4A-10(Homo sapiens (Human))
Boston College

LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Boston College

LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Boston College

LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boston College

LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Boston College

LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Boston College

LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50:  110nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Boston College

LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50:  110nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIsoform PDE2A2 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A2)(Homo sapiens (Human))
Boston College

US Patent
LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Boston College

US Patent
LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIsoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1)(Homo sapiens (Human))
Boston College

US Patent
LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Boston College

LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Boston College

LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boston College

LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Boston College

LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed