BDBM8744 1-[(4-methylphenyl)methyl]-4-(thiophen-3-yl)-1H-imidazole::Disubstituted imidazole 23

SMILES Cc1ccc(Cn2cnc(c2)-c2ccsc2)cc1

InChI Key InChIKey=DHBTWCAOUVLMCW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8744   

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
Glaxosmithkline

LigandPNGBDBM8744(1-[(4-methylphenyl)methyl]-4-(thiophen-3-yl)-1H-im...)
Affinity DataIC50:  250nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM8744(1-[(4-methylphenyl)methyl]-4-(thiophen-3-yl)-1H-im...)
Affinity DataIC50:  3.92E+3nMAssay Description:Inhibition of Escherichia coli FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
Glaxosmithkline

LigandPNGBDBM8744(1-[(4-methylphenyl)methyl]-4-(thiophen-3-yl)-1H-im...)
Affinity DataIC50:  360nMAssay Description:Inhibition of Staphylococcus aureus FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rateMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM8744(1-[(4-methylphenyl)methyl]-4-(thiophen-3-yl)-1H-im...)
Affinity DataIC50:  6.44E+3nMT: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed