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Report error Found 114 Enz. Inhib. hit(s) with Target = 'ATP-binding cassette sub-family C member 8'
TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50025834(CHEMBL3330880)
Affinity DataKd:  0.380nMAssay Description:Binding affinity to SUR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50025847(CHEMBL3330879)
Affinity DataKd:  2.10nMAssay Description:Binding affinity to SUR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMed
LigandPNGBDBM50118351(6-chloro-3-(1-methylcyclobutyl)-amino-4H-thieno[3,...)
Affinity DataIC50: 3nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human SUR1/Kir6.2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50153520(CHEMBL1272 | AGEE-623ZW | 2-Ethoxy-4-{[(S)-3-methy...)
Affinity DataKd:  50nMAssay Description:Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50139706(3-(2,4-Dinitro-phenyl)-4-nitro-5-trifluoromethyl-1...)
Affinity DataEC50:  70nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50378565(CHEMBL568795)
Affinity DataEC50:  80nMAssay Description:Activation of human recombinant SUR1/Kir6.2 channel expressed in HEK293 cells assessed as increase in ionic current by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50190500(6-chloro-3-(1-methyl-1-phenylethyl)amino-4H-thieno...)
Affinity DataIC50: 81nMAssay Description:Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50153521(2-Methoxy-4-{[(S)-3-methyl-1-(2-piperidin-1-yl-phe...)
Affinity DataKd:  83nMAssay Description:Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50153520(CHEMBL1272 | AGEE-623ZW | 2-Ethoxy-4-{[(S)-3-methy...)
Affinity DataIC50: 106nMAssay Description:In vitro displacement of [3H]glibenclamide (IC50=0.61) from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50118349((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50: 120nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50153522(2-(2-Fluoro-ethoxy)-4-{[(S)-3-methyl-1-(2-piperidi...)
Affinity DataKd:  134nMAssay Description:Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50190502(6-bromo-3-(1-methylcyclopropyl)amino-4H-thieno[3,2...)
Affinity DataEC50:  160nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50153521(2-Methoxy-4-{[(S)-3-methyl-1-(2-piperidin-1-yl-phe...)
Affinity DataIC50: 163nMAssay Description:In vitro displacement of [3H]glibenclamide (IC50=0.61) from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50118348((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50: 180nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50190500(6-chloro-3-(1-methyl-1-phenylethyl)amino-4H-thieno...)
Affinity DataEC50:  180nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  190nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  190nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50119272((7-Chloro-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1...)
Affinity DataEC50:  196nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50119272((7-Chloro-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1...)
Affinity DataEC50:  200nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Rat)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50363009(CHEMBL1946412)
Affinity DataIC50: 200nMAssay Description:Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50118360(tert-Butyl-(2-chloro-7,7-dioxo-4,7-dihydro-1,7lamb...)
Affinity DataIC50: 230nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Rat)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50363013(CHEMBL191539)
Affinity DataIC50: 240nMAssay Description:Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50130735((7-chloro-1,1-dioxo-1,4-dihydro-benzo[1,2,4]thiadi...)
Affinity DataEC50:  250nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Rat)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50363006(CHEMBL363989)
Affinity DataIC50: 280nMAssay Description:Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50153522(2-(2-Fluoro-ethoxy)-4-{[(S)-3-methyl-1-(2-piperidi...)
Affinity DataIC50: 281nMAssay Description:In vitro displacement of [3H]glibenclamide (IC50=0.61) from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataIC50: 286nMAssay Description:Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataIC50: 320nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50118343((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50: 340nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Rat)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50363004(CHEMBL1946140)
Affinity DataIC50: 350nMAssay Description:Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50119269(Cyclobutyl-(7-fluoro-1,1-dioxo-1,4-dihydro-1lambda...)
Affinity DataEC50:  356nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50119269(Cyclobutyl-(7-fluoro-1,1-dioxo-1,4-dihydro-1lambda...)
Affinity DataEC50:  400nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  450nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as activation of K+ currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Rat)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50130735((7-chloro-1,1-dioxo-1,4-dihydro-benzo[1,2,4]thiadi...)
Affinity DataIC50: 480nMAssay Description:Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Rat)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50363007(CHEMBL1946272)
Affinity DataIC50: 520nMAssay Description:Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50119274(Cyclobutyl-(7-nitro-1,1-dioxo-1,4-dihydro-1lambda*...)
Affinity DataEC50:  530nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50190501(6-chloro-3-{[1-(trifluoromethyl)cyclopropyl]-amino...)
Affinity DataEC50:  530nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50139709(3-(2,4-Bis-trifluoromethyl-phenyl)-4-nitro-5-trifl...)
Affinity DataEC50:  540nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Rat)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50362998(CHEMBL1945810)
Affinity DataIC50: 620nMAssay Description:Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50023475(CHEMBL2111887)
Affinity DataIC50: 640nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50139705(4-Nitro-3-(4-nitro-phenyl)-5-trifluoromethyl-1H-py...)
Affinity DataEC50:  700nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Rat)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50363002(CHEMBL115565)
Affinity DataIC50: 760nMAssay Description:Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50190496(6-chloro-3-(1-phenylcyclopropyl)amino-4H-thieno[3,...)
Affinity DataEC50:  810nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50139704(3-(2,4-Difluoro-phenyl)-4-nitro-5-trifluoromethyl-...)
Affinity DataEC50:  1.15E+3nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Rat)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50363003(CHEMBL1946139)
Affinity DataIC50: 1.41E+3nMAssay Description:Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Rat)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50363008(CHEMBL1946410)
Affinity DataIC50: 1.67E+3nMAssay Description:Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Rat)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50362992(CHEMBL1946411)
Affinity DataIC50: 1.73E+3nMAssay Description:Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Rat)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50363011(CHEMBL189093)
Affinity DataIC50: 1.75E+3nMAssay Description:Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Rat)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50362991(CHEMBL1946273)
Affinity DataIC50: 1.81E+3nMAssay Description:Activation of SUR1 in rat pancreatic islets assessed as inhibition of glucose-induced insulin secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50119270(Cyclobutyl-(1,1-dioxo-1,4-dihydro-1lambda*6*-benzo...)
Affinity DataEC50:  1.96E+3nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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