Compile Data Set for Download or QSAR
Report error Found 3762 Enz. Inhib. hit(s) with Target = 'ATP-dependent translocase ABCB1'
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50265387(CHEMBL4099415)
Affinity DataEC50:  329nMAssay Description:Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity by measuring compound concentration required ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50265388(CHEMBL4097071)
Affinity DataEC50:  120nMAssay Description:Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity by measuring compound concentration required ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50268560(CHEMBL4093128)
Affinity DataEC50:  253nMAssay Description:Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50464784(CHEMBL4290541)
Affinity DataEC50:  3.04E+3nMAssay Description:Inhibition of human MDR1 expressed in MDCK-MDR1 cells assessed as calcein cell accumulation after 30 mins by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50464785(CHEMBL4292641)
Affinity DataEC50:  7.64E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK-MDR1 cells assessed as calcein cell accumulation after 30 mins by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353847(CHEMBL1831157 | US9604926, Compound CM-360 | US972...)
Affinity DataEC50:  6.09E+3nMAssay Description:Inhibition of human MDR1 expressed in MDCK-MDR1 cells assessed as calcein cell accumulation after 30 mins by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353845(CHEMBL1830149 | US9604926, Compound CM-341 | US972...)
Affinity DataEC50:  460nMAssay Description:Inhibition of human MDR1 expressed in MDCK-MDR1 cells assessed as calcein cell accumulation after 30 mins by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50464787(CHEMBL4293027)
Affinity DataEC50:  1.10E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK-MDR1 cells assessed as calcein cell accumulation after 30 mins by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50464783(CHEMBL4285825)
Affinity DataEC50:  2.83E+3nMAssay Description:Inhibition of human MDR1 expressed in MDCK-MDR1 cells assessed as calcein cell accumulation after 30 mins by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480837(CHEMBL573373)
Affinity DataEC50:  1.31E+3nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480838(CHEMBL574166)
Affinity DataEC50:  2.25E+3nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480839(CHEMBL572801)
Affinity DataEC50:  1.31E+3nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50354361(GNF-PF-2787 | CHEMBL575039)
Affinity DataEC50:  2.65E+3nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480840(CHEMBL572576)
Affinity DataEC50:  2.24E+3nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480841(CHEBI:1263 | CHEMBL584140)
Affinity DataEC50:  1.02E+3nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480842(CHEMBL575236)
Affinity DataEC50: >1.00E+5nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480843(CHEMBL575455)
Affinity DataEC50:  4.15E+3nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480844(CHEMBL573023)
Affinity DataEC50:  1.55E+3nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480845(CHEMBL573940)
Affinity DataEC50:  640nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480846(CHEMBL584572)
Affinity DataEC50:  3.98E+3nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480847(CHEMBL582864)
Affinity DataEC50:  1.52E+3nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480848(CHEMBL573943)
Affinity DataEC50:  900nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480849(CHEMBL582915)
Affinity DataEC50: >1.00E+5nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480850(CHEMBL575668)
Affinity DataEC50:  970nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480851(CHEMBL572575)
Affinity DataEC50:  1.92E+3nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480852(CHEMBL573419)
Affinity DataEC50:  4.59E+3nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480853(CHEMBL573009)
Affinity DataEC50:  640nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480854(CHEMBL583181)
Affinity DataEC50:  560nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480855(CHEMBL573233)
Affinity DataEC50:  1.10E+3nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480856(CHEMBL575044)
Affinity DataEC50:  460nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50480857(CHEMBL582890)
Affinity DataEC50:  1.21E+3nMAssay Description:Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50409816(ABAMECTIN)
Affinity DataKd:  11nMAssay Description:TP_TRANSPORTER: binding in plasma membranes from CEM/VLB1.0 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50492250(CHEMBL2398178)
Affinity DataEC50:  1.31E+3nMAssay Description:Inhibition of p-gp in human KB/VCR cells assessed as potentiation of 100 nM docetaxel-induced cytotoxicity after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataEC50:  1.25E+3nMAssay Description:Inhibition of p-gp in human KB/VCR cells assessed as potentiation of 100 nM docetaxel-induced cytotoxicity after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50492251(CHEMBL2398097)
Affinity DataEC50:  1.37E+3nMAssay Description:Inhibition of p-gp in human KB/VCR cells assessed as potentiation of 100 nM docetaxel-induced cytotoxicity after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50495099(CHEMBL3105705)
Affinity DataEC50:  110nMAssay Description:Modulation of p-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversal of paclitaxel resistanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50495100(CHEMBL3105238)
Affinity DataEC50:  94nMAssay Description:Modulation of p-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversal of paclitaxel resistanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataEC50:  32nMAssay Description:Modulation of p-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversal of paclitaxel resistanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataEC50:  446nMAssay Description:Modulation of p-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversal of paclitaxel resistanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50505434(CHEMBL4472194)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50465868(CHEMBL4279851)
Affinity DataEC50:  526nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50505430(CHEMBL4552591)
Affinity DataEC50:  679nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50505445(CHEMBL4278790)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50505447(CHEMBL4279706)
Affinity DataEC50:  560nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50505448(CHEMBL4291239)
Affinity DataEC50:  210nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50465857(CHEMBL4279545)
Affinity DataEC50:  155nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50305083(Ko143 | Ko-143 | 3-((3S,6S)-6-Isobutyl-9-methoxy-1...)
Affinity DataEC50:  943nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as potentiation of mitoxantrone-induced cytotoxicity after 5 days by MT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50465863(CHEMBL4290127)
Affinity DataEC50:  300nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50505458(CHEMBL4453052)
Affinity DataEC50: >2.00E+3nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as potentiation of mitoxantrone-induced cytotoxicity after 5 days by MT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50465852(CHEMBL4290384)
Affinity DataEC50:  201nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
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