Report error Found 391 Enz. Inhib. hit(s) with Target = 'Adenosylhomocysteinase'
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataKi: 0.0100nMAssay Description:Inhibition of SAH hydrolase (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataKi: 0.5nMAssay Description:Compound was tested for inhibition of S-adenosyl homocysteine (SAH) hydrolase. More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:As a consequence of "D"-Isoneplanocin and "L"-Isoneplanocin, being isomers of Neplanocin A, which on one hand is a potent inhibitor of S-adenosylhomo...More data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant human AHCY using SAH as substrate assessed as formation of homocysteine after 10 minsMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Inhibition of human recombinant S-adenosyl-L-homocysteine hydrolase assessed as AdoHcy hydrolysis activity by Lineweaver-Burk plotMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:As a consequence of "D"-Isoneplanocin and "L"-Isoneplanocin, being isomers of Neplanocin A, which on one hand is a potent inhibitor of S-adenosylhomo...More data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Binding affinity against L929 cells AdoHcy hydrolase activityMore data for this Ligand-Target Pair
Affinity DataIC50: 3.19nMAssay Description:As a consequence of "D"-Isoneplanocin and "L"-Isoneplanocin, being isomers of Neplanocin A, which on one hand is a potent inhibitor of S-adenosylhomo...More data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataKi: 3.30nMAssay Description:Compound was tested for inhibition of S-adenosyl homocysteine (SAH) hydrolase. More data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataKi: 3.80nMAssay Description:Evaluated for the 50% inhibition of bovine-liver S-Adenosyl-homocysteine (AdoHcy) hydrolaseMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataKi: 3.80nMAssay Description:Inhibitory activity against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy) rate of inactivation by NpcAMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataKi: 3.80nMAssay Description:Time course of inactivation of bovine liver S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Binding affinity against S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human S-adenosyl-L-homocysteine hydrolase assessed as hydrolysis of AdoHcy after 8 mins by HPLC analysisMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant S-adenosyl-L-homocysteine hydrolase assessed as AdoHcy hydrolysis activity by HPLC analysisMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 7.20nMAssay Description:Tested for inhibitory concentration against S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of S-adenosyl-homocysteine (AdoHcy)hydrolase from rabbit erythrocytesMore data for this Ligand-Target Pair
Affinity DataKi: 8.40nMAssay Description:Reversible inhibition of rat liver S- adenosyl-L-homocysteine hydrolase using SAH as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibition of recombinant human S-adenosyl-L-homocysteine hydrolase assessed as hydrolysis of AdoHcy after 8 mins by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 8.70nMAssay Description:Inhibition of SAHase from rabbit erythrocytes using S-adenosyl-L-homocysteine as substrate preincubated for 5 mins followed by substrate addition and...More data for this Ligand-Target Pair
Affinity DataIC50: 9.30nMAssay Description:As a consequence of "D"-Isoneplanocin and "L"-Isoneplanocin, being isomers of Neplanocin A, which on one hand is a potent inhibitor of S-adenosylhomo...More data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 9.40nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataKi: 11.1nMAssay Description:Binding affinity against L929 cells AdoHcy hydrolase activityMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Inhibitory activity against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy) rate of inactivation by NpcAMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human S-adenosyl-L-homocysteine hydrolase assessed as hydrolysis of AdoHcy after 8 mins by HPLC analysisMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant S-adenosyl-L-homocysteine hydrolase assessed as AdoHcy hydrolysis activity by HPLC analysisMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 15.2nMAssay Description:Inhibitory activity against S-adenosyl-L-homocysteine hydrolase from rabbit erythrocytesMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 15.2nMAssay Description:Inhibitory effect against S-adenosyl-L-homocysteine hydrolase of rabbit erythrocyte.More data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human AHCY using SAH as substrate assessed as formation of homocysteine after 10 minsMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Tested for inhibitory concentration against S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataKi: 22nMAssay Description:Inhibitory activity against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy) rate of inactivation by NpcAMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant human AHCY using SAH as substrate assessed as formation of homocysteine after 10 minsMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Inhibitory activity against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy) rate of inactivation by NpcAMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:As a consequence of "D"-Isoneplanocin and "L"-Isoneplanocin, being isomers of Neplanocin A, which on one hand is a potent inhibitor of S-adenosylhomo...More data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of S-adenosyl-L-homocysteine hydrolase in intact rat hepatocytesMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Tested for inhibitory concentration against S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataKi: 35nMAssay Description:Time course of inactivation of bovine liver S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataKi: 39nMAssay Description:Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant.More data for this Ligand-Target Pair
Affinity DataKi: 39nMAssay Description:Inhibitory activity against recombinant rat liver S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Human)
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital of Guangdong Medical University
Curated by ChEMBL
Affinity DataKi: 39nMAssay Description:concentration dependent inhibition of S-Adenosyl-homocysteine hydrolase was determined by Kitz and Wilson methodMore data for this Ligand-Target Pair
Affinity DataKi: 39nMAssay Description:Inhibitory activity against recombinant rat liver S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
Affinity DataKi: 39nMAssay Description:Compound was tested for its inhibitory activity against recombinant rat liver S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair






3D Structure (crystal)

























