Compile Data Set for Download or QSAR
Report error Found 876 Enz. Inhib. hit(s) with Target = 'C-C chemokine receptor type 4'
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50255479(CHEMBL4067429)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at CCR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380881(CHEMBL2018953)
Affinity DataEC50:  10nMAssay Description:Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50500895(CHEMBL3797462)
Affinity DataEC50:  398nMAssay Description:Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50500896(CHEMBL3799393)
Affinity DataEC50:  6.30nMAssay Description:Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50500894(CHEMBL3799578)
Affinity DataEC50:  16nMAssay Description:Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50500893(CHEMBL3797662)
Affinity DataEC50:  158nMAssay Description:Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50500902(CHEMBL3798452)
Affinity DataEC50:  13nMAssay Description:Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50142347(2-[(2R,5R)-5-[(3-Chloro-2-methyl-benzylcarbamoyl)-...)
Affinity DataEC50:  2.00E+3nMAssay Description:Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50142370(2-{(2R,5R)-2-(2,4-Dichloro-phenyl)-5-[((R)-1-napht...)
Affinity DataEC50:  600nMAssay Description:Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380881(CHEMBL2018953)
Affinity DataKd:  50.1nMAssay Description:Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin conte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380868(CHEMBL2018955)
Affinity DataKd:  6.31E+3nMAssay Description:Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin conte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380872(CHEMBL2018959)
Affinity DataKd:  2.51E+3nMAssay Description:Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin conte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380882(CHEMBL2018951)
Affinity DataKd:  6.31E+3nMAssay Description:Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin conte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380875(CHEMBL2018961)
Affinity DataKd:  1.00E+3nMAssay Description:Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin conte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380867(CHEMBL2018964)
Affinity DataKd:  1.00E+3nMAssay Description:Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin conte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380866(CHEMBL2018967)
Affinity DataKd:  2.00E+3nMAssay Description:Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin conte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380879(CHEMBL2018968)
Affinity DataKd:  631nMAssay Description:Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin conte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380884(CHEMBL2018954)
Affinity DataKd:  251nMAssay Description:Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin conte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380876(CHEMBL2018952)
Affinity DataKd:  1.58E+3nMAssay Description:Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin conte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380880(CHEMBL2018969)
Affinity DataKd:  631nMAssay Description:Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin conte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50278725(CHEMBL4172769)
Affinity DataIC50: 0.316nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50278758(CHEMBL4167445)
Affinity DataIC50: 0.631nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50278799(CHEMBL4162364)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at mouse CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50278793(CHEMBL4160218)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50198429((S)-(4-(4-(2,4-dichlorobenzylamino)pyrido[2,3-d]py...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Dog)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at dog CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380884(CHEMBL2018954)
Affinity DataIC50: 3.89nMAssay Description:Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380884(CHEMBL2018954)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380884(CHEMBL2018954)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380884(CHEMBL2018954)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50278727(CHEMBL4173046)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50278794(CHEMBL4175323)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50278797(CHEMBL4160846)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human CCR4 expressed in HEK cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50378979(CHEMBL2011441)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at mouse CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380881(CHEMBL2018953)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380881(CHEMBL2018953)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380881(CHEMBL2018953)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50380881(CHEMBL2018953)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50545768(CHEMBL4641127)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50490515(CHEMBL2326611)
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50490519(CHEMBL2326625)
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50490519(CHEMBL2326625)
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50198429((S)-(4-(4-(2,4-dichlorobenzylamino)pyrido[2,3-d]py...)
Affinity DataIC50: 7nMAssay Description:Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM236789(US9388149, 20 | US9580412, Example 20)
Affinity DataIC50: 7.20nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
US Patent

TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50278787(CHEMBL4173861)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50278801(CHEMBL4165356)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50500893(CHEMBL3797662)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
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