Compile Data Set for Download or QSAR
Report error Found 360 Enz. Inhib. hit(s) with Target = 'Cytochrome c'
TargetCytochrome c1, heme protein, mitochondrial(Homo sapiens)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  0.550nMAssay Description:Binding affinity to human CYC1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome c oxidase assembly protein COX14(Homo sapiens)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  5nMAssay Description:Binding affinity to human COX14 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50587908(CHEMBL5193790)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of ovine COX-2 colorimetric enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50587909(CHEMBL5174073)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of ovine COX-2 colorimetric enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 1(Sheep)
Itel Telecomunicazioni

US Patent
LigandPNGBDBM679764(US12011433, Compound mofezolac)
Affinity DataIC50: 7.90nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetCytochrome c oxidase subunit 6A1, mitochondrial(Homo sapiens)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  8.90nMAssay Description:Binding affinity to human COX6A1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 6C(Homo sapiens)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  12nMAssay Description:Binding affinity to human COX6C incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 1(Sheep)
Itel Telecomunicazioni

US Patent
LigandPNGBDBM679777(US12011433, Compound MPA361)
Affinity DataIC50: 13nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetCytochrome c oxidase subunit NDUFA4(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50172374(2,2-Dimethyl-6-[1-(3,4,5-trimethoxy-benzyl)-vinyl]...)
Affinity DataIC50: 18nMAssay Description:Inhibitory concentration against NADH ubiquinone oxidoreductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit NDUFA4(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50172374(2,2-Dimethyl-6-[1-(3,4,5-trimethoxy-benzyl)-vinyl]...)
Affinity DataIC50: 18nMAssay Description:Inhibitory concentration against NADH-ubiquinone oxidoreductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50029600(CHEMBL42485 | 5-bromo-2-(4-fluorophenyl)-3-(4-(met...)
Affinity DataIC50: 21nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant COX-2 using [1-14C] arachidonic acid as substrate preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome c1, heme protein, mitochondrial(Homo sapiens)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  29nMAssay Description:Binding affinity to human CYC1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50229774(N-hydroxy-4-(5-methyl-3-phenylisoxazol-4-yl)benzen...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant cyclooxygenase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 43nMAssay Description:Inhibition of ovine COX-2 colorimetric enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 1(Sheep)
Itel Telecomunicazioni

US Patent
LigandPNGBDBM679784(US12011433, Compound MPA439)
Affinity DataIC50: 49nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetCytochrome c oxidase subunit NDUFA4(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50172381(2,2-Dimethyl-2H-chromene-6-carboxylic acid 3,4,5-t...)
Affinity DataIC50: 55nMAssay Description:Inhibitory concentration against NADH-ubiquinone oxidoreductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit NDUFA4(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50172381(2,2-Dimethyl-2H-chromene-6-carboxylic acid 3,4,5-t...)
Affinity DataIC50: 55nMAssay Description:Inhibitory concentration against NADH ubiquinone oxidoreductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50326830(2-(4-azido)phenyl)-8-benzoyl-quinoline-4-carboxyli...)
Affinity DataIC50: 57nMAssay Description:Inhibition of sheep COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50635952(CHEMBL5568253)
Affinity DataIC50: 58nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 60nMAssay Description:Inhibition of sheep COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50326828(8-benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-...)
Affinity DataIC50: 69nMAssay Description:Inhibition of sheep COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus infected Sf21 cells using arachidonic acid as substrate preincubated for 5 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 1(Sheep)
Itel Telecomunicazioni

US Patent
LigandPNGBDBM679768(US12011433, Compound MPA195)
Affinity DataIC50: 70nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetCytochrome c oxidase subunit 2(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50635949(CHEMBL5565096)
Affinity DataIC50: 75nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50326829(6-benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-...)
Affinity DataIC50: 77nMAssay Description:Inhibition of sheep COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50326831(2-(4-azido)phenyl)-6-benzoyl-quinoline-4-carboxyli...)
Affinity DataIC50: 77nMAssay Description:Inhibition of sheep COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50326826(2-(4-acetamido)phenyl)-8-benzoyl-quinoline-4-carbo...)
Affinity DataIC50: 80nMAssay Description:Inhibition of sheep COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 1(Sheep)
Itel Telecomunicazioni

US Patent
LigandPNGBDBM679782(US12011433, Compound MPA462)
Affinity DataIC50: 80nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50326827(2-(4-acetamido)phenyl)-6-benzoyl-quinoline-4-carbo...)
Affinity DataIC50: 85nMAssay Description:Inhibition of sheep COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM679785(US12011433, Compound MPA450)
Affinity DataIC50: 90nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 90nMAssay Description:Inhibition of ovine COX-2 using arachidonic acid as substrate measured after 2 mins by colorimetric enzyme immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50300870(2-(4-(methylsulfonyl)phenyl)-quinoline-4-carboxyli...)
Affinity DataIC50: 91nMAssay Description:Inhibition of sheep COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 1(Sheep)
Itel Telecomunicazioni

US Patent
LigandPNGBDBM679770(US12011433, Compound MPA190)
Affinity DataIC50: 100nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetCytochrome c oxidase subunit 1(Sheep)
Itel Telecomunicazioni

US Patent
LigandPNGBDBM679767(US12011433, Compound GAMOF11)
Affinity DataIC50: 100nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM679775(US12011433, Compound MPA236)
Affinity DataIC50: 100nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetCytochrome c oxidase subunit 1(Sheep)
Itel Telecomunicazioni

US Patent
LigandPNGBDBM679765(US12011433, Compound GlaMOF0)
Affinity DataIC50: 100nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetCytochrome c(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  107nMAssay Description:Binding affinity to human CYCS incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50587914(CHEMBL5200917)
Affinity DataIC50: 110nMAssay Description:Inhibition of ovine COX-2 using arachidonic acid as substrate measured after 2 mins by colorimetric enzyme immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM679777(US12011433, Compound MPA361)
Affinity DataIC50: 120nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetCytochrome c oxidase subunit 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50343721(3-(4-(4-(2-fluoro-4-methylphenyl)-5-(4-methoxyphen...)
Affinity DataIC50: 130nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50635950(CHEMBL5568511)
Affinity DataIC50: 134nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50635951(CHEMBL5568474)
Affinity DataIC50: 144nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 1(Sheep)
Itel Telecomunicazioni

US Patent
LigandPNGBDBM679781(US12011433, Compound MPA415)
Affinity DataIC50: 150nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
US Patent

TargetCytochrome c oxidase subunit 2(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  153nMAssay Description:Binding affinity to human MT-CO2 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 160nMAssay Description:Inhibition of ovine COX-2 by colorimetric inhibitor screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50587915(CHEMBL5196989)
Affinity DataIC50: 170nMAssay Description:Inhibition of ovine COX-2 using arachidonic acid as substrate measured after 2 mins by colorimetric enzyme immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50598758(CHEMBL5199117)
Affinity DataIC50: 190nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50343722(3-(4-(5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-(2...)
Affinity DataIC50: 240nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
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