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Report error Found 342 Enz. Inhib. hit(s) with Target = 'G protein-activated inward rectifier potassium channel 1'
TargetG protein-activated inward rectifier potassium channel 1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataEC50:  0.0372nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affliation: Vanderbilt University Grant Title: Measurement of GPCR-mediated thallium flux through GI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2011
Entry Details
PCBioAssay
TargetG protein-activated inward rectifier potassium channel 1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;perchlorate | 2-...)
Affinity DataEC50:  0.0614nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affliation: Vanderbilt University Grant Title: Measurement of GPCR-mediated thallium flux through GI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2011
Entry Details
PCBioAssay
TargetG protein-activated inward rectifier potassium channel 1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM73209(cid_657346 | methamilane methiodide | trimethyl-[[...)
Affinity DataEC50:  0.280nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affliation: Vanderbilt University Grant Title: Measurement of GPCR-mediated thallium flux through GI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2011
Entry Details
PCBioAssay
TargetG protein-activated inward rectifier potassium channel 1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM73210(SMR000030412 | MLS000094859 | (5Z)-5-{(2E)-3-[4-(d...)
Affinity DataEC50:  0.856nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affliation: Vanderbilt University Grant Title: Measurement of GPCR-mediated thallium flux through GI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2011
Entry Details
PCBioAssay
TargetG protein-activated inward rectifier potassium channel 1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataEC50:  1.49nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affliation: Vanderbilt University Grant Title: Measurement of GPCR-mediated thallium flux through GI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2011
Entry Details
PCBioAssay
LigandPNGBDBM585716(US11530213, Example 37 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 6nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585717(US11530213, Example 38 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 8nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585727(US11530213, Example 48 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 9nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585715(US11530213, Example 36 | N-(2-((8-chloro-1-(2,6- d...)
Affinity DataIC50: 9nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585729(US11530213, Example 50 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 11nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585741(US11530213, Example 62)
Affinity DataIC50: 13nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585719(US11530213, Example 40 | 8-chloro-1-(2,6-chlorophe...)
Affinity DataIC50: 13nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585738(US11530213, Example 59)
Affinity DataIC50: 14nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585721(US11530213, Example 42 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 15nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585718(US11530213, Example 39 | (S)-8-chloro-1-(2,6- dich...)
Affinity DataIC50: 15nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585742(US11530213, Example 63)
Affinity DataIC50: 16nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585737(US11530213, Example 58)
Affinity DataIC50: 17nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585764(US11530213, Example 85)
Affinity DataIC50: 19nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585760(US11530213, Example 81)
Affinity DataIC50: 23nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585768(US11530213, Example 89)
Affinity DataIC50: 24nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585709(US11530213, Example 30 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 25nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585694(US11530213, Example 15 | 5-(2,5,8,11,14,17- hexaox...)
Affinity DataIC50: 25nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585722(US11530213, Example 43 | 3,5-dichloro-4-(8-chloro-...)
Affinity DataIC50: 26nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585732(US11530213, Example 53 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 28nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585720(US11530213, Example 41 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 28nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585733(US11530213, Example 54 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 29nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM695825(US12084442, Example 18 | 3-((8-Chloro-1-(2,6-dichl...)
Affinity DataIC50: 30nMAssay Description:The GIRK1/4 activity of a compound according to the present invention was assessed by the following in vitro method.Buffers:a. External buffer: 10 mM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

LigandPNGBDBM695823(US12084442, Example 16 | 3-((8-Chloro-1-(2,6-dichl...)
Affinity DataIC50: 30nMAssay Description:The GIRK1/4 activity of a compound according to the present invention was assessed by the following in vitro method.Buffers:a. External buffer: 10 mM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

LigandPNGBDBM585705(US11530213, Example 26 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 31nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585736(US11530213, Example 57 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 32nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

TargetG protein-activated inward rectifier potassium channel 1(Human)
University of Nebraska

Curated by ChEMBL
LigandPNGBDBM50593405(CHEMBL5178783)
Affinity DataEC50:  33nMAssay Description:Activation of GIRK1/2 channel (unknown origin) expressed in HEK293 cells incubated for 6 mins by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM585711(US11530213, Example 32 | 8-chloro-1-(2,6-dichloro-...)
Affinity DataIC50: 33nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585745(US11530213, Example 66)
Affinity DataIC50: 34nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585714(US11530213, Example 35 | 5-((2-(1H-imidazol-4- yl)...)
Affinity DataIC50: 35nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585691(US11530213, Example 12 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 36nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585765(US11530213, Example 86)
Affinity DataIC50: 37nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585707(US11530213, Example 28 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 39nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585770(US11530213, Example 91)
Affinity DataIC50: 40nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585730(US11530213, Example 51 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 41nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585728(US11530213, Example 49 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 42nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585772(US11530213, Example 93)
Affinity DataIC50: 46nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585771(US11530213, Example 92)
Affinity DataIC50: 47nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM695826(US12084442, Example 19 | N-(3-(8-Chloro-1-(2,6-dic...)
Affinity DataIC50: 50nMAssay Description:The GIRK1/4 activity of a compound according to the present invention was assessed by the following in vitro method.Buffers:a. External buffer: 10 mM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

LigandPNGBDBM695827(US12084442, Example 20 | 8-Chloro-1-(2,6-dichloro-...)
Affinity DataIC50: 50nMAssay Description:The GIRK1/4 activity of a compound according to the present invention was assessed by the following in vitro method.Buffers:a. External buffer: 10 mM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

LigandPNGBDBM585693(US11530213, Example 14 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 52nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585734(US11530213, Example 55 | 3-chloro-2-(8-chloro-2- c...)
Affinity DataIC50: 54nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585723(US11530213, Example 44 | 3,5-dichloro-4-(8-chloro-...)
Affinity DataIC50: 56nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585726(US11530213, Example 47 | 8-chloro-1-(2,6-dichlorop...)
Affinity DataIC50: 59nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM585696(US11530213, Example 17 | 3-((8-chloro-1-(2,6- dich...)
Affinity DataIC50: 60nMAssay Description:Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM695820(US12084442, Example 13 | (S)-3-((8-Chloro-1-(2,6-d...)
Affinity DataIC50: 60nMAssay Description:The GIRK1/4 activity of a compound according to the present invention was assessed by the following in vitro method.Buffers:a. External buffer: 10 mM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

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