Compile Data Set for Download or QSAR
Report error Found 2544 Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic, NMDA 1/2B'
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474799(CHEMBL416690)
Affinity DataKi:  0.400nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451786(CHEMBL423244)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451785(CHEMBL159675)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474791(CHEMBL65693)
Affinity DataKi:  0.680nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124885(N-(2-methoxybenzyl)cinnamamidine | (E)-N-(2-Methox...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451505(CHEMBL274422)
Affinity DataIC50: 0.700nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474791(CHEMBL65693)
Affinity DataIC50: 0.720nMAssay Description:In vitro inhibition of Glu/Gly stimulated [Ca2+] influx in LtK-cells expressing the hNR1a/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451789(CHEMBL159762)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474809(CHEMBL65454)
Affinity DataKi:  0.820nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474789(CHEMBL68134)
Affinity DataKi:  0.850nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataKi:  0.990nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataKi:  0.990nMAssay Description:Binding affinity to NR1/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276468(US10071988, Example 407 | 2-[[1-[3-(Difluoromethyl...)
Affinity DataIC50: 1nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276467(US10071988, Example 406 | 5-Chloro-2-[[1-[3-(diflu...)
Affinity DataIC50: 1nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276535(US10071988, Example 475 | 2-[[1-(4-Fluoro-3-methyl...)
Affinity DataIC50: 1nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276139(2-[[1-[4-Chloro-3-(difluoromethyl)phenyl]triazol-4...)
Affinity DataIC50: 1nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276144(2-[[1-[3-(Difluoromethyl)-4-fluoro-phenyl]triazol-...)
Affinity DataIC50: 1nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276109(2-[[1-(3-Bromo-4-fluoro-phenyl)triazol-4-yl]methox...)
Affinity DataIC50: 1nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276134(2-[[1-(3-Bromo-4-fluoro-phenyl)triazol-4-yl]methox...)
Affinity DataIC50: 1nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276133(2-[[1-(3-Bromo-4-fluoro-phenyl)triazol-4-yl]methox...)
Affinity DataIC50: 1nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276124(US10071988, Example 154 | 2-[[1-[4-Chloro-3-(diflu...)
Affinity DataIC50: 1nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276540(US10071988, Example 480 | 2-[[1-(4-Fluoro-3-methyl...)
Affinity DataIC50: 1nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276506(US10071988, Example 446 | 2-[[1-[4-Fluoro-3-(trifl...)
Affinity DataIC50: 1nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276538(US10071988, Example 478 | 5-Ethyl-2-[[1-(4-fluoro-...)
Affinity DataIC50: 1nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276537(US10071988, Example 477 | 2-[[1-(4-Fluoro-3-methyl...)
Affinity DataIC50: 1nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451766(CHEMBL159761)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276542(US10071988, Example 482 | 5-Chloro-2-[[1-(4-fluoro...)
Affinity DataIC50: 1nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474796(CHEMBL64941)
Affinity DataKi:  1.10nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474796(CHEMBL64941)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to NR1/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451778(CHEMBL159416)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at human NR1a/NR2B receptor expressed in mouse fibroblast LMTK cells assessed as inhibition of Glu/Gly induced Ca2+ influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451772(CHEMBL159453)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451769(CHEMBL159902)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143890(2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H](E)-N1-(2-methoxybenzyl)cinnamamidine from human NR1a/NR2b receptor expressed in mouse Ltk cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143890(2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol...)
Affinity DataKi:  1.5nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451784(CHEMBL159790)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451779(CHEMBL160027)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451503(CHEMBL12513)
Affinity DataIC50: 1.80nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataIC50: 1.90nMAssay Description:In vitro inhibition of Glu/Gly stimulated [Ca2+] influx in LtK-cells expressing the hNR1a/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451780(CHEMBL161859)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM409275(2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...)
Affinity DataIC50: 2nMAssay Description:Modulation of recombinant human GluN1/GluN2B NMDA receptor expressed in mammalian cells assessed as inhibition of glutamate/glycine-induced intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50140341(6-(3-(4-(4-fluorobenzyl)piperidin-1-yl)prop-1-ynyl...)
Affinity DataIC50: 2nMAssay Description:Binding affinity against NR1A/2B receptor in rat brains by [3H]ifenprodil displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276115(2-[[1-[4-Chloro-3-(difluoromethoxy)phenyl]triazol-...)
Affinity DataIC50: 2nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM436977(US10617676, Example 312 | 1-[(4-Methyl-3-pyridyl)m...)
Affinity DataIC50: 2nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276114(2-[[1-[4-Chloro-3-(difluoromethoxy)phenyl]triazol-...)
Affinity DataIC50: 2nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276312(4,5-Dimethyl-2-[[1-(m-tolyl)triazol-4-yl]methoxy]p...)
Affinity DataIC50: 2nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276536(US10071988, Example 476 | 5-Chloro-2-[[1-(4-fluoro...)
Affinity DataIC50: 2nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276469(US10071988, Example 408 | 2-[[1-[3-(Difluoromethyl...)
Affinity DataIC50: 2nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM276363(2-[[1-[3-(1,1-Difluoroethyl)phenyl]triazol-4-yl]me...)
Affinity DataIC50: 2nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50502547(CHEMBL4581662)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ifenprodil from GluN1a/GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by solid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
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