Compile Data Set for Download or QSAR
Report error Found 800 Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic, NMDA 2A'
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50038046(2-((S)-9-Bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-...)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50591723(CHEMBL5185347)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50038055(((S)-9-Bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-py...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50591726(CHEMBL450325)
Affinity DataIC50: 2.60nMAssay Description:Displacement of [3H]L-689560 from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50038047(2-(9-Bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyri...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50591722(CHEMBL5208012)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50284815(2-((S)-9-Chloro-6-methyl-2,3-dioxo-2,3,6,7-tetrahy...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50591721(CHEMBL5208606)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50284813(((S)-9-Chloro-6-methyl-2,3-dioxo-2,3,6,7-tetrahydr...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50591725(CHEMBL61720)
Affinity DataIC50: 4.40nMAssay Description:Displacement of [3H]L-689560 from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50059777((2R,6S)-3-((R)-2-Methoxy-propyl)-6,11,11-trimethyl...)
Affinity DataKi:  4.5nMAssay Description:Antagonist activity at NMDA receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50284817((9-Chloro-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyrid...)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50284818(2-(9-Chloro-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyr...)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50591724(CHEMBL129149)
Affinity DataKi:  9.60nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50038043((9-Bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyrido...)
Affinity DataKi:  9.90nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50069483(N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrahydro-quinoxalin...)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]MDL from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50069459(Thiophene-3-carboxylic acid (7-bromo-2,3-dioxo-1,2...)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]MDL from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50069465(Thiophene-2-carboxylic acid (7-bromo-2,3-dioxo-1,2...)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]MDL from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50599749(CHEMBL5171984)
Affinity DataEC50:  11nMAssay Description:Positive allosteric modulator activity at GluN2A receptor (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521725(US11149056, Compound U6472)
Affinity DataEC50:  13nMAssay Description:Cells are transferred as suspension in serum-free medium to the QPatch HTX system and kept in the cell storage tank/stirrer during experiments. All s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393276(US9963434, Table 12.219 | 5-(3,4- difluorobenzenes...)
Affinity DataIC50: 16.2nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393246(US9963434, Table 12.189 | 5-(3-chloro-4- fluoroben...)
Affinity DataIC50: 19.6nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50344263((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at NR2A transfected in oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM86494(Perzinfotel | WAY-126090 | EAA-090)
Affinity DataIC50: 30nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521564(US11149054, Compound 1-B)
Affinity DataEC50:  31.6nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521614(US11149054, Compound 5131)
Affinity DataEC50:  33.6nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521682(US11149054, Compound 9062)
Affinity DataEC50:  34.5nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Rat)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50171881((E)-(R)-2-Amino-4-methyl-5-phosphono-pent-3-enoic ...)
Affinity DataIC50: 35nMAssay Description:Inhibition of [3H]CPP binding to rat N-methyl-D-aspartic acid receptor 2AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521593(US11149054, Compound 3496)
Affinity DataEC50:  35.1nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50599750(CHEMBL5180445)
Affinity DataEC50:  39nMAssay Description:Positive allosteric modulator activity at GluN2A receptor (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393274(US9963434, Table 12.217 | 5-(3- chlorobenzenesulfo...)
Affinity DataIC50: 39.5nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521617(US11149054, Compound 3886)
Affinity DataEC50:  53.4nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393080(US9963434, Table 12.26 | 5-(3-chloro-4- fluorobenz...)
Affinity DataIC50: 61nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521588(US11149054, Compound 3035)
Affinity DataEC50:  61nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521651(US11149054, Compound 7468)
Affinity DataEC50:  61.4nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521582(US11149054, Compound 2500)
Affinity DataEC50:  63.3nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Rat)
University of Copenhagen

LigandPNGBDBM213889(5,7-Dichlorokynurenic acid (5,7-DCKA))
Affinity DataKi:  65nM ΔG°:  -41.0kJ/mole IC50: 92nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521578(US11149054, Compound 2184)
Affinity DataEC50:  65.8nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521703(US11149054, Compound 10949)
Affinity DataEC50:  66.4nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521591(US11149054, Compound 3382)
Affinity DataEC50:  67.6nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521589(US11149054, Compound 3149)
Affinity DataEC50:  69.7nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataIC50: 70nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521672(US11149054, Compound 8379)
Affinity DataEC50:  73.4nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521667(US11149054, Compound 8361)
Affinity DataEC50:  87nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393273(US9963434, Table 12.216 | 5-(3-chloro-4- fluoroben...)
Affinity DataIC50: 87.8nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521598(US11149054, Compound 3983)
Affinity DataEC50:  88.1nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50591726(CHEMBL450325)
Affinity DataIC50: 90nMAssay Description:Displacement of [3H]NMDA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521704(US11149054, Compound 4115)
Affinity DataEC50:  91.9nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2A(Rat)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50004927(Selfotel | 4-Phosphonomethyl-piperidine-2-carboxyl...)
Affinity DataIC50: 95nMAssay Description:Inhibition of [3H]CPP binding to rat N-methyl-D-aspartic acid receptor 2AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM521647(US11149054, Compound 7282)
Affinity DataEC50:  95.9nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

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