Compile Data Set for Download or QSAR
Report error Found 487 Enz. Inhib. hit(s) with Target = 'Heme oxygenase 1'
TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50315700(CHEMBL4161975)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant HO-1 by spectrometry based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50207198(1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanol hy...)
Affinity DataIC50: 60nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50315700(CHEMBL4161975)
Affinity DataIC50: 60nMAssay Description:Inhibition of HO-1 in Sprague-Dawley albino rat spleen microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2020
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50438658(CHEMBL1188560)
Affinity DataIC50: 60nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50207205(1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanone h...)
Affinity DataIC50: 110nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50207201(4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanol h...)
Affinity DataIC50: 140nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50648802(CHEMBL5613041)
Affinity DataKd:  141nMAssay Description:Binding affinity to avi-tagged HO-1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM651772(US20240051952, Example 124 | N-(2-methoxyethoxy)-1...)
Affinity DataEC50:  200nMAssay Description:Measurement of HMOX1 ( HO-1 ) 1. In a polypropylene 384 well plate, human HO-1(after reconstitution in PBS+0.5% Triton+1 mM EDTA) was serially dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50526839(CHEMBL4586392)
Affinity DataIC50: 225nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO-1 preincubated for 10 mins followed by beta-NADPH addition and measured after 15 mins by gas chr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50526821(CHEMBL4583097)
Affinity DataIC50: 240nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO-1 preincubated for 10 mins followed by beta-NADPH addition and measured after 15 mins by gas chr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50526835(CHEMBL4520773)
Affinity DataIC50: 250nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO-1 preincubated for 10 mins followed by beta-NADPH addition and measured after 15 mins by gas chr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50535263(CHEMBL4456149)
Affinity DataIC50: 250nMAssay Description:Inhibition of human recombinant HO-1 by spectrometry based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50315702(CHEMBL4166126)
Affinity DataIC50: 270nMAssay Description:Inhibition of HO-1 in rat spleen microsomes incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50315702(CHEMBL4166126)
Affinity DataIC50: 270nMAssay Description:Inhibition of HO-1 in Sprague-Dawley albino rat spleen microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2020
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50183064((2S,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazo...)
Affinity DataIC50: 270nMAssay Description:Inhibition of HO-1 in Sprague-Dawley albino rat spleen microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2020
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50315702(CHEMBL4166126)
Affinity DataIC50: 270nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO-1 assessed as bilirubin formation incubated for 60 mins by double-beam spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31673(imidazole-dioxolane, 25)
Affinity DataIC50: 280nMpH: 7.4 T: 2°CAssay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31768(Nizoral | CHEMBL295698 | Panfungol | Ketoconazole)
Affinity DataIC50: 300nMpH: 7.4 T: 2°CAssay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2009
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 300nMAssay Description:Inhibition of rat spleen microsome HO-1 preincubated for 10 mins followed by beta-NADPH addition and measured after 15 mins by gas chromatographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM651692(US20240051952, Example 33 | N-(2-hydroxyethyl)-1- ...)
Affinity DataEC50:  300nMAssay Description:Measurement of HMOX1 ( HO-1 ) 1. In a polypropylene 384 well plate, human HO-1(after reconstitution in PBS+0.5% Triton+1 mM EDTA) was serially dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM651773(US20240051952, Example 125 | N-(2-hydroxyethoxy)- ...)
Affinity DataEC50:  300nMAssay Description:Measurement of HMOX1 ( HO-1 ) 1. In a polypropylene 384 well plate, human HO-1(after reconstitution in PBS+0.5% Triton+1 mM EDTA) was serially dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31653(CHEMBL421109 | imidazole-dioxolane, 5)
Affinity DataIC50: 330nMpH: 7.4 T: 2°CAssay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31653(CHEMBL421109 | imidazole-dioxolane, 5)
Affinity DataIC50: 330nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO-1 preincubated for 10 mins followed by beta-NADPH addition and measured after 15 mins by gas chr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM651732(US20240051952, Example 75 | 1-(2-methoxyethyl)-2- ...)
Affinity DataEC50:  370nMAssay Description:Measurement of HMOX1 ( HO-1 ) 1. In a polypropylene 384 well plate, human HO-1(after reconstitution in PBS+0.5% Triton+1 mM EDTA) was serially dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50526824(CHEMBL4436773)
Affinity DataIC50: 390nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO-1 preincubated for 10 mins followed by beta-NADPH addition and measured after 15 mins by gas chr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50252802(4-(4-Bromophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-buta...)
Affinity DataIC50: 390nMAssay Description:Inhibition of HO1 in rat spleen microsomal fraction assessed as carbon monoxide productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50315703(CHEMBL4177406)
Affinity DataIC50: 400nMAssay Description:Inhibition of HO-1 in Sprague-Dawley albino rat spleen microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2020
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50526840(CHEMBL4514212)
Affinity DataIC50: 400nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO-1 preincubated for 10 mins followed by beta-NADPH addition and measured after 15 mins by gas chr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM651771(US20240051952, Example 122 | N-(2-(dimethylamino)-...)
Affinity DataEC50:  400nMAssay Description:Measurement of HMOX1 ( HO-1 ) 1. In a polypropylene 384 well plate, human HO-1(after reconstitution in PBS+0.5% Triton+1 mM EDTA) was serially dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31769(cid_5404 | Terconazole)
Affinity DataIC50: 410nMpH: 7.4 T: 2°CAssay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2009
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50375318(Fungistat | Gyno-Terazol | Panlomyc | R-42470 | Te...)
Affinity DataIC50: 410nMAssay Description:Inhibition of rat spleen microsome HO-1 preincubated for 10 mins followed by beta-NADPH addition and measured after 15 mins by gas chromatographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50183074(4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol ...)
Affinity DataIC50: 500nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM651774(US20240051952, Example 126 | N-(2-hydroxyethoxy)-1...)
Affinity DataEC50:  500nMAssay Description:Measurement of HMOX1 ( HO-1 ) 1. In a polypropylene 384 well plate, human HO-1(after reconstitution in PBS+0.5% Triton+1 mM EDTA) was serially dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM651775(US20240051952, Example 127 | N-(2-methoxyethoxy)-1...)
Affinity DataEC50:  500nMAssay Description:Measurement of HMOX1 ( HO-1 ) 1. In a polypropylene 384 well plate, human HO-1(after reconstitution in PBS+0.5% Triton+1 mM EDTA) was serially dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM651691(US20240051952, Example 32 | N-(2-methoxyethyl)-1- ...)
Affinity DataEC50:  500nMAssay Description:Measurement of HMOX1 ( HO-1 ) 1. In a polypropylene 384 well plate, human HO-1(after reconstitution in PBS+0.5% Triton+1 mM EDTA) was serially dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50315696(CHEMBL4177101)
Affinity DataIC50: 500nMAssay Description:Inhibition of HO-1 in Sprague-Dawley albino rat spleen microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2020
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50315706(CHEMBL4161217)
Affinity DataIC50: 500nMAssay Description:Inhibition of HO-1 in Sprague-Dawley albino rat spleen microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2020
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31653(CHEMBL421109 | imidazole-dioxolane, 5)
Affinity DataIC50: 520nMAssay Description:In vitro inhibitory concentration against heme oxygenase 1 from rat spleenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31671(imidazole-dioxolane, 23)
Affinity DataIC50: 590nMpH: 7.4 T: 2°CAssay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM651768(US20240051952, Example 119 | 2-(benzo[d]oxazol-2-y...)
Affinity DataEC50:  600nMAssay Description:Measurement of HMOX1 ( HO-1 ) 1. In a polypropylene 384 well plate, human HO-1(after reconstitution in PBS+0.5% Triton+1 mM EDTA) was serially dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM651703(US20240051952, Example 45 | N-(2-methoxyethyl)-1- ...)
Affinity DataEC50:  640nMAssay Description:Measurement of HMOX1 ( HO-1 ) 1. In a polypropylene 384 well plate, human HO-1(after reconstitution in PBS+0.5% Triton+1 mM EDTA) was serially dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50648800(CHEMBL5614205)
Affinity DataKd:  648nMAssay Description:Binding affinity to avi-tagged HO-1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM651726(US20240051952, Example 69 | 2-((6-fluorobenzo[d]- ...)
Affinity DataEC50:  660nMAssay Description:Measurement of HMOX1 ( HO-1 ) 1. In a polypropylene 384 well plate, human HO-1(after reconstitution in PBS+0.5% Triton+1 mM EDTA) was serially dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31677(imidazole-dioxolane, 29)
Affinity DataIC50: 670nMpH: 7.4 T: 2°CAssay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM651698(US20240051952, Example 40 | N-(2-(2-(dimethyl- ami...)
Affinity DataEC50:  690nMAssay Description:Measurement of HMOX1 ( HO-1 ) 1. In a polypropylene 384 well plate, human HO-1(after reconstitution in PBS+0.5% Triton+1 mM EDTA) was serially dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50648811(CHEMBL5613604)
Affinity DataKd:  692nMAssay Description:Binding affinity to avi-tagged HO-1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM84847(CHEMBL558183 | 1-azolyl-4-phenyl-2-butanone, 49a)
Affinity DataIC50: 700nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetHeme oxygenase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM651717(US20240051952, Example 60 | 2-((6-isopropylbenzo- ...)
Affinity DataEC50:  700nMAssay Description:Measurement of HMOX1 ( HO-1 ) 1. In a polypropylene 384 well plate, human HO-1(after reconstitution in PBS+0.5% Triton+1 mM EDTA) was serially dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM84847(CHEMBL558183 | 1-azolyl-4-phenyl-2-butanone, 49a)
Affinity DataIC50: 700nMpH: 7.4 T: 2°CAssay Description:Heme oxygenase activity in rat spleen and brain microsomal fractions was determined by the quantitation of CO formed from the degradation of methemal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2012
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31659(imidazole-dioxolane, 11)
Affinity DataIC50: 700nMpH: 7.4 T: 2°CAssay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
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