Compile Data Set for Download or QSAR
Report error Found 666 Enz. Inhib. hit(s) with Target = 'Inhibitor of nuclear factor kappa-B kinase subunit alpha'
LigandPNGBDBM18207(dexamethasone (tetramethyl-rhodamine conjugated ) ...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of IKKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human IKKa using KKKKERLLDDRHDSGLDSMKDEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  5.80nMAssay Description:Binding constant for IKK-alpha kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandPNGBDBM396920(US9981963, Compound 11)
Affinity DataIC50: 6nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

LigandPNGBDBM50395537(CHEMBL2164411)
Affinity DataIC50: 6.31nMAssay Description:Inhibition of IKK1 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50395536(CHEMBL2164412)
Affinity DataIC50: 6.31nMAssay Description:Inhibition of IKK1 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50395538(CHEMBL2164410)
Affinity DataIC50: 6.31nMAssay Description:Inhibition of IKK1 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50294677(7-(3-fluorophenyl)-N,1-dimethyl-1,6-dihydroimidazo...)
Affinity DataIC50: 7nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM50294680(3-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5...)
Affinity DataIC50: 7nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM50395531(CHEMBL2164417)
Affinity DataIC50: 7.94nMAssay Description:Inhibition of IKK1 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50294679(7-(3-methoxyphenyl)-N,1-dimethyl-1,6-dihydroimidaz...)
Affinity DataIC50: 8nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  9nMAssay Description:Binding constant for IKK-alpha kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandPNGBDBM396916(US9981963, Compound 7)
Affinity DataIC50: 9nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  9nMAssay Description:Binding affinity to IKK-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
LigandPNGBDBM396918(US9981963, Compound 9)
Affinity DataIC50: 9nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

LigandPNGBDBM396919(US9981963, Compound 10)
Affinity DataIC50: 9nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

LigandPNGBDBM396936(US9981963, Compound 31)
Affinity DataIC50: 9nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

LigandPNGBDBM396924(US9981963, Compound 15)
Affinity DataIC50: 10nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

LigandPNGBDBM50576853(CHEMBL4859206)
Affinity DataIC50: 11nMAssay Description:Inhibition of IKKalpha (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50576851(CHEMBL1876217)
Affinity DataIC50: 11nMAssay Description:Inhibition of IKKalpha (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50576853(CHEMBL4859206)
Affinity DataIC50: 11nMAssay Description:Inhibition of IKKalpha (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50294681(7-(3-(aminomethyl)phenyl)-N,1-dimethyl-1,6-dihydro...)
Affinity DataIC50: 11nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM50576851(CHEMBL1876217)
Affinity DataIC50: 11nMAssay Description:Inhibition of IKKalpha (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50294687(3-methoxy-N-(3-(1-methyl-4-(methylamino)-1,6-dihyd...)
Affinity DataIC50: 12nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM50395539(CHEMBL483165)
Affinity DataIC50: 12.6nMAssay Description:Inhibition of IKK1 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50395539(CHEMBL483165)
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant IKK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50294682(N-(3-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[...)
Affinity DataIC50: 14nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM396922(US9981963, Compound 13)
Affinity DataIC50: 14nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

LigandPNGBDBM396934(US9981963, Compound 25)
Affinity DataIC50: 14nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

LigandPNGBDBM396914(US9981963, Compound 5)
Affinity DataIC50: 16nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

LigandPNGBDBM50576852(CHEMBL4849098)
Affinity DataIC50: 16nMAssay Description:Inhibition of IKKalpha (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50576852(CHEMBL4849098)
Affinity DataIC50: 16nMAssay Description:Inhibition of IKKalpha (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
LigandPNGBDBM396923(US9981963, Compound 14)
Affinity DataIC50: 18nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

LigandPNGBDBM396915(US9981963, Compound 6)
Affinity DataIC50: 19nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

LigandPNGBDBM396917(US9981963, Compound 8)
Affinity DataIC50: 21nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

LigandPNGBDBM50294686(N1-(3-(1-methyl-4-(methylamino)-1,6-dihydroimidazo...)
Affinity DataIC50: 22nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM50294683(2-hydroxy-N-(3-(1-methyl-4-(methylamino)-1,6-dihyd...)
Affinity DataIC50: 25nMAssay Description:Inhibition of IKK1-catalyzed phosphorylation of GST-tagged IkappaBalpha fusion protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM50149806(2''-Amino-6''-(2-hydroxy-phenyl)-1,2,3,4,5,6-hexah...)
Affinity DataIC50: 25nMAssay Description:Inhibition of I-kappa-B-kinase alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50395535(CHEMBL2164413)
Affinity DataIC50: 25.1nMAssay Description:Inhibition of IKK1 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM396913(US9981963, Compound 4)
Affinity DataIC50: 28nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

LigandPNGBDBM396929(US9981963, Compound 20)
Affinity DataIC50: 29nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

LigandPNGBDBM396935(US9981963, Compound 30)
Affinity DataIC50: 29nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

LigandPNGBDBM50175701((4-(4-(5-(3-amino-3-methylbutyl)thiophen-2-yl)pyri...)
Affinity DataIC50: 30nMAssay Description:Inhibitory activity against IKK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50175690((4-(4-(5-(3-amino-3-ethylpentyl)thiophen-2-yl)pyri...)
Affinity DataIC50: 30nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50175690((4-(4-(5-(3-amino-3-ethylpentyl)thiophen-2-yl)pyri...)
Affinity DataIC50: 30nMAssay Description:Inhibitory activity against IKK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50395533(CHEMBL2164415)
Affinity DataIC50: 31.6nMAssay Description:Inhibition of IKK1 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50293532(1-(3-(5-(4-(aminomethyl)phenyl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50: 32nMAssay Description:Inhibition of IKK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50271752(CHEMBL4128114)
Affinity DataIC50: 32nMAssay Description:Inhibition of IKK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
LigandPNGBDBM50413877(CHEMBL482540)
Affinity DataIC50: 32nMAssay Description:Inhibition of human recombinant IKK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 33nMAssay Description:Inhibition of IKK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Displayed 1 to 50 (of 666 total ) | Next | Last >>
Jump to: