Compile Data Set for Download or QSAR
Report error Found 585 Enz. Inhib. hit(s) with Target = 'Lanosterol synthase'
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50055641(3-[(3E,7E,11E)-14-(1,5-Dimethyl-hex-4-enylsulfanyl...)
Affinity DataIC50: 0.220nMAssay Description:Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from Candida albicansMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Yeast)
Sinhgad College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50055641(3-[(3E,7E,11E)-14-(1,5-Dimethyl-hex-4-enylsulfanyl...)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of Candida albicans OSCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50494940(CHEMBL3098189)
Affinity DataKi:  0.600nMAssay Description:Inhibition of IMPDH1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50130785(CHEMBL609978 | CHEMBL542453 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50130785(CHEMBL609978 | CHEMBL542453 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 1.90nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50450452(CHEMBL4167128)
Affinity DataIC50: 2nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50450454(CHEMBL4174978)
Affinity DataIC50: 2nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50055642(2,2-Dimethyl-3-[(3E,7E,11E)-3,7,12-trimethyl-15-(4...)
Affinity DataIC50: 2.30nMAssay Description:Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from Candida albicansMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128063(CHEMBL67133 | CHEMBL112210 | Allyl-{6-[3-(4-bromo-...)
Affinity DataIC50: 2.88nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128063(CHEMBL67133 | CHEMBL112210 | Allyl-{6-[3-(4-bromo-...)
Affinity DataIC50: 2.90nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128063(CHEMBL67133 | CHEMBL112210 | Allyl-{6-[3-(4-bromo-...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imagingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128063(CHEMBL67133 | CHEMBL112210 | Allyl-{6-[3-(4-bromo-...)
Affinity DataIC50: 2.90nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128063(CHEMBL67133 | CHEMBL112210 | Allyl-{6-[3-(4-bromo-...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50494929(CHEMBL3098184)
Affinity DataKi:  3nMAssay Description:Inhibition of IMPDH1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50271572(1-[4-Chlorophenylcarbonyl]-4-[4-(pyridin-4-yl)phen...)
Affinity DataIC50: 3nMAssay Description:Inhibition of 2,3-oxidosqualene-lanosterol cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128060({4-[4-(Allyl-methyl-amino)-but-2-enyloxy]-phenyl}-...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50450473(CHEMBL4170443)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128054(N-allyl-6-(1-(4-bromophenyl)isoquinolin-6-yloxy)-N...)
Affinity DataIC50: 3.47nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128054(N-allyl-6-(1-(4-bromophenyl)isoquinolin-6-yloxy)-N...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128054(N-allyl-6-(1-(4-bromophenyl)isoquinolin-6-yloxy)-N...)
Affinity DataIC50: 3.5nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128054(N-allyl-6-(1-(4-bromophenyl)isoquinolin-6-yloxy)-N...)
Affinity DataIC50: 3.5nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50450450(CHEMBL4172614)
Affinity DataIC50: 4nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50450447(CHEMBL4171117)
Affinity DataIC50: 4nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128055(CHEMBL66638 | CHEMBL115085 | Allyl-{6-[4-(4-bromo-...)
Affinity DataIC50: 4.07nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128055(CHEMBL66638 | CHEMBL115085 | Allyl-{6-[4-(4-bromo-...)
Affinity DataIC50: 4.10nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128055(CHEMBL66638 | CHEMBL115085 | Allyl-{6-[4-(4-bromo-...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128055(CHEMBL66638 | CHEMBL115085 | Allyl-{6-[4-(4-bromo-...)
Affinity DataIC50: 4.10nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50130788(CHEMBL611484 | CHEMBL116705 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 4.10nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50130788(CHEMBL611484 | CHEMBL116705 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50133285((E)-3-Carboxy-acrylateallyl-{6-[4-(4-chloro-benzoy...)
Affinity DataIC50: 4.30nMAssay Description:Tested for Oxidosqualene-lanosterol cyclase inhibition in Trypanosoma bruceiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50130783(CHEMBL115020 | CHEMBL611485 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 4.60nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50133285((E)-3-Carboxy-acrylateallyl-{6-[4-(4-chloro-benzoy...)
Affinity DataIC50: 4.60nMAssay Description:Tested for Oxidosqualene-lanosterol cyclase inhibition in Pneumocystis cariniiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50130783(CHEMBL115020 | CHEMBL611485 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50255431(4-(trifluoromethyl)phenyl 4-(5-(allyl(methyl)amino...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imagingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128050(CHEMBL114259 | CHEMBL416694 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 5.37nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128050(CHEMBL114259 | CHEMBL416694 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128050(CHEMBL114259 | CHEMBL416694 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 5.40nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128050(CHEMBL114259 | CHEMBL416694 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 5.40nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50130789(Allyl-{6-[3-(4-bromo-phenyl)-benzo[b]thiophen-6-yl...)
Affinity DataIC50: 5.60nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50494941(CHEMBL3098187)
Affinity DataKi:  5.60nMAssay Description:Inhibition of IMPDH1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50128065({4-[6-(Allyl-methyl-amino)-hexyloxy]-2-fluoro-phen...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imagingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50271622(1-[4-Chlorophenylsulfonyl]-4-[4-(4-methylpiperazin...)
Affinity DataIC50: 6nMAssay Description:Inhibition of 2,3-oxidosqualene-lanosterol cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50130786(CHEMBL611486 | CHEMBL115923 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50130786(CHEMBL611486 | CHEMBL115923 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 6.20nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50130774(CHEMBL611757 | CHEMBL115375 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of oxidosqualene cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50529561(CHEMBL4462175)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
Lieber Institute For Brain Development

Curated by ChEMBL
LigandPNGBDBM50450465(CHEMBL4177089)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Human)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50130774(CHEMBL611757 | CHEMBL115375 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50: 6.30nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
Displayed 1 to 50 (of 585 total ) | Next | Last >>
Jump to: