Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with Target = 'Leucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,A2016T]'
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,A2016T](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM481879(US10913744, Compound 18 | (4-((5-chloro-4-(methyla...)
Affinity DataIC50: 47.7nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,A2016T](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM482159(GSK2578215A | BDBM50401284)
Affinity DataIC50: 81.1nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,A2016T](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 93.3nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,A2016T](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM482160(HG-10-102-01 | BDBM50396041)
Affinity DataIC50: 154nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,A2016T](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM482157(LRRK2-IN-1 | BDBM50379529 | US11370796, Compound L...)
Affinity DataIC50: 2.45E+3nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)