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Report error Found 41 Enz. Inhib. hit(s) with Target = 'NEDD8-activating enzyme E1 regulatory subunit'
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50594972(CHEMBL5177755)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 4nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 4nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50651690(CHEMBL5633567)
Affinity DataIC50: 4nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50427034(CHEMBL2322194)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50427035(CHEMBL2017005)
Affinity DataIC50: 10nMAssay Description:Inhibition of NAE (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM762712(US12378251, Compound S14)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762711(US12378251, Compound S13)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762700(US12378251, Compound S2)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762554(US12378251, Compound S1)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762718(US12378251, Compound S20)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762702(US12378251, Compound S4)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762701(US12378251, Compound S3)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM393526(US9963456, Example Comp. | US12378251, Compound ML...)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM762704(US12378251, Compound S6)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762706(US12378251, Compound S8)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762708(US12378251, Compound S10)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762707(US12378251, Compound S9)
Affinity DataIC50: 100nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 180nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50574026(CHEMBL4282603)
Affinity DataIC50: 260nMAssay Description:Inhibition of NAE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM762710(US12378251, Compound S12)
Affinity DataIC50: 550nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762713(US12378251, Compound S15)
Affinity DataIC50: 550nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762703(US12378251, Compound S5)
Affinity DataIC50: 550nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762705(US12378251, Compound S7)
Affinity DataIC50: 550nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50427031(CHEMBL2322197)
Affinity DataIC50: 800nMAssay Description:Inhibition of NAE (unknown origin)-catalyzed NEDD8-Ubcl2 intermediate formation by densitometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM762709(US12378251, Compound S11)
Affinity DataIC50: 1.00E+3nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762714(US12378251, Compound S16)
Affinity DataIC50: 1.00E+3nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762716(US12378251, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762715(US12378251, Compound S17)
Affinity DataIC50: 1.00E+3nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762717(US12378251, Compound S19)
Affinity DataIC50: 1.00E+3nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762719(US12378251, Compound S21)
Affinity DataIC50: 1.00E+3nMAssay Description:1. Preliminary Evaluation Experiment of Inhibiting NAE Enzyme Activity at the Molecular Level by CompoundsHomogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of NAE-mediated Ubcl2-NEDD8 conjugation in human Caco2 cells after 16 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50537681(CHEMBL4640167)
Affinity DataEC50:  3.56E+3nMAssay Description:Inhibition of NAE-mediated neddylation in human MGC-803 cells assessed as effect on NEDD8-UBC12 coupling product formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50537681(CHEMBL4640167)
Affinity DataEC50:  3.56E+3nMAssay Description:Inhibition of NAE-mediated neddylation in human MGC803 cells assessed as reduction in Nedd8-Ubcl2 adduct formation incubated for 24 hrs by Western bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50427032(6,6''-Biapigenin | CHEMBL2322196)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of NAE (unknown origin) assessed as decrease in NEDD8-Ubcl2 formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50562350(CHEMBL4788522)
Affinity DataIC50: 5.51E+3nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50562351(CHEMBL4746177)
Affinity DataIC50: 6.67E+3nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50562352(CHEMBL4744561)
Affinity DataIC50: 9.94E+3nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50651689(CHEMBL5632724)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50318907(CHEMBL1014 | TCV-116 | candesartancilexetil | Atac...)
Affinity DataIC50: 1.64E+4nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50427032(6,6''-Biapigenin | CHEMBL2322196)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NAE (unknown origin)-catalyzed transthiolation of NEDD8 from NAE to Ubc12More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed