Compile Data Set for Download or QSAR
Report error Found 181 Enz. Inhib. hit(s) with Target = 'NPC1-like intracellular cholesterol transporter 1'
TargetNPC1-like intracellular cholesterol transporter 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50300992((2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-3-[(S)-3-(4-Fluoro-...)
Affinity DataIC50: 4nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNPC1-like intracellular cholesterol transporter 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50300992((2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-3-[(S)-3-(4-Fluoro-...)
Affinity DataIC50: 4nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50300992((2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-3-[(S)-3-(4-Fluoro-...)
Affinity DataIC50: 4nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50300992((2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-3-[(S)-3-(4-Fluoro-...)
Affinity DataIC50: 4nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258479((2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorop...)
Affinity DataIC50: 7nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258479((2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorop...)
Affinity DataIC50: 16nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258479((2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorop...)
Affinity DataIC50: 20nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50300992((2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-3-[(S)-3-(4-Fluoro-...)
Affinity DataIC50: 44nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045524(CHEMBL3311502)
Affinity DataEC50:  86nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50300993((2S,3S,4S,5R,6S)-6-{4-[(2S,3R)-3-[(3S)-3-(4-fluoro...)
Affinity DataIC50: 127nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50300993((2S,3S,4S,5R,6S)-6-{4-[(2S,3R)-3-[(3S)-3-(4-fluoro...)
Affinity DataIC50: 150nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045525(CHEMBL3311372)
Affinity DataEC50:  150nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50300993((2S,3S,4S,5R,6S)-6-{4-[(2S,3R)-3-[(3S)-3-(4-fluoro...)
Affinity DataIC50: 173nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50240720((2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-1-(4-Fluoro-phenyl)...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50371521(EZETIMIBE)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50300993((2S,3S,4S,5R,6S)-6-{4-[(2S,3R)-3-[(3S)-3-(4-fluoro...)
Affinity DataIC50: 200nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045527(CHEMBL3311373)
Affinity DataEC50:  290nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50240720((2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-1-(4-Fluoro-phenyl)...)
Affinity DataIC50: 300nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50240720((2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-1-(4-Fluoro-phenyl)...)
Affinity DataIC50: 300nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045530(CHEMBL3311500)
Affinity DataEC50:  360nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045529(CHEMBL3311374)
Affinity DataEC50:  360nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045531(CHEMBL3311498)
Affinity DataEC50:  370nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50371521(EZETIMIBE)
Affinity DataIC50: 370nMAssay Description:Inhibition of NPC1L1 (unknown origin) assessed as inhibition of cholesterol cellular uptake by BCA colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258548((1-(1-naphthoyl)-5-phenylpiperidin-3-yl)(spiro[ind...)
Affinity DataIC50: 390nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045532(CHEMBL3311379)
Affinity DataEC50:  560nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50240720((2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-1-(4-Fluoro-phenyl)...)
Affinity DataIC50: 580nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332397(2,2,6,6-tetramethylpiperidin-4-yl 2-(8-(4-cyclohex...)
Affinity DataIC50: 600nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258480(((2S,4S)-1-benzoyl-4-phenylpyrrolidin-2-yl)(spiro[...)
Affinity DataIC50: 660nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045533(CHEMBL3311378)
Affinity DataEC50:  840nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045534(CHEMBL3311371)
Affinity DataEC50:  880nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332389(ethyl 1-(2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl...)
Affinity DataIC50: 900nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332404(2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-tr...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332437(tert-butyl 4-(2-(8-(4-tert-butylbenzoyl)-4-oxo-1-p...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045535(CHEMBL3311377)
Affinity DataEC50:  1.00E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332446(8-(4-cyclohexylbenzoyl)-3-(2-oxo-2-(piperidin-1-yl...)
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332452(8-(4-cyclohexylbenzoyl)-3-(2-(4-(hydroxymethyl)pip...)
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50300993((2S,3S,4S,5R,6S)-6-{4-[(2S,3R)-3-[(3S)-3-(4-fluoro...)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332396(2,2,6,6-tetramethylpiperidin-4-yl 2-(8-(4-tert-but...)
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50371519(CHEMBL271655)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045536(CHEMBL3311369)
Affinity DataEC50:  1.40E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045537(CHEMBL3311218)
Affinity DataEC50:  1.50E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332429(tert-butyl(2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phen...)
Affinity DataIC50: 1.70E+3nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045541(CHEMBL2418972)
Affinity DataEC50:  1.70E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045540(CHEMBL3311217)
Affinity DataEC50:  1.70E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045539(CHEBI:28082 | 3Beta,5Alpha,6Beta-Trihydroxycholest...)
Affinity DataEC50:  1.70E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045538(CHEMBL1277915)
Affinity DataEC50:  1.70E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045542(CHEMBL3311376)
Affinity DataEC50:  1.80E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045543(CHEMBL3311219)
Affinity DataEC50:  1.90E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332426(2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-tr...)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332435(2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-tr...)
Affinity DataIC50: 2.10E+3nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
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