Compile Data Set for Download or QSAR
Report error Found 1499 Enz. Inhib. hit(s) with Target = 'Neurotensin receptor type 1'
TargetNeurotensin receptor type 1(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50240845(2-{(S)-2-[2-({(S)-1-[(S)-2-((S)-2-Amino-5-guanidin...)
Affinity DataEC50:  0.0100nMAssay Description:Agonist activity at rat NTS1 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50281791(Ac-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH | CHEMBL...)
Affinity DataKi:  0.0130nMAssay Description:Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetNeurotensin receptor type 1(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50240845(2-{(S)-2-[2-({(S)-1-[(S)-2-((S)-2-Amino-5-guanidin...)
Affinity DataKi:  0.0180nMAssay Description:Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetNeurotensin receptor type 1(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50240845(2-{(S)-2-[2-({(S)-1-[(S)-2-((S)-2-Amino-5-guanidin...)
Affinity DataKi:  0.0180nMAssay Description:Binding affinity to NTR1 in mouse brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50124132(CHEMBL3622802)
Affinity DataIC50: 0.0200nMAssay Description:Displacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50281781(Ac-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH | CHEMBL2645...)
Affinity DataKi:  0.0240nMAssay Description:Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetNeurotensin receptor type 1(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130880(pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-L...)
Affinity DataEC50:  0.0400nMAssay Description:Agonist activity at rat NTS1 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50048908(CHEMBL415788)
Affinity DataEC50:  0.0420nMAssay Description:Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM693834(US20240287046, Compound II-3)
Affinity DataIC50: 0.0600nMAssay Description:The binding affinities of test compounds were determined by a radioligand competitive binding assay using 177Lu labeled C-1 as the reference radiolig...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM693821(US20240287046, Compound I-4)
Affinity DataIC50: 0.0600nMAssay Description:The binding affinities of test compounds were determined by a radioligand competitive binding assay using 177Lu labeled C-1 as the reference radiolig...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetNeurotensin receptor type 1(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50286859(2-{2-[(S)-2-({1-[(S)-6-Amino-2-((S)-(S)-2,6-diamin...)
Affinity DataKi:  0.0600nMAssay Description:Compound was tested in vitro for its binding affinity against Neurotensin Receptor after peripheral administrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM693820(US20240287046, Compound I-3)
Affinity DataIC50: 0.0620nMAssay Description:The binding affinities of test compounds were determined by a radioligand competitive binding assay using 177Lu labeled C-1 as the reference radiolig...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetNeurotensin receptor type 1(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50240339(CHEMBL266571 | Neurotensin 2 | 2-{(R)-(S)-2-[(S)-2...)
Affinity DataKi:  0.0640nMAssay Description:Compound was tested in vitro for its binding affinity against Neurotensin Receptor after peripheral administrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50048908(CHEMBL415788)
Affinity DataEC50:  0.0692nMAssay Description:Agonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50342242((S)-2-((2S,3S)-2-((S)-2-((S)-1-((S)-6-amino-2-((S)...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of human NTR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNeurotensin receptor type 1(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50281785((S)-2-{2-[(S)-2-{[(S)-1-((S)-2-{(S)-2-[((S)-1-Acet...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetNeurotensin receptor type 1(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50286864((S)-2-{(S)-2-[(S)-2-({(R)-1-[5-Guanidino-2-(3-guan...)
Affinity DataKi:  0.100nMAssay Description:Compound was tested in vitro for its binding affinity against Neurotensin Receptor after peripheral administrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetNeurotensin receptor type 1(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50240339(CHEMBL266571 | Neurotensin 2 | 2-{(R)-(S)-2-[(S)-2...)
Affinity DataKi:  0.110nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50281793(Ac-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu...)
Affinity DataKi:  0.110nMAssay Description:Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM693833(US20240287046, Compound II-2)
Affinity DataIC50: 0.110nMAssay Description:The binding affinities of test compounds were determined by a radioligand competitive binding assay using 177Lu labeled C-1 as the reference radiolig...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetNeurotensin receptor type 1(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50281795(Ac-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH | CH...)
Affinity DataKi:  0.120nMAssay Description:Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50048908(CHEMBL415788)
Affinity DataKi:  0.129nMAssay Description:Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50240844((S)-2-{2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Acetylamino-...)
Affinity DataKi:  0.130nMAssay Description:Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM693826(US20240287046, Compound I-9)
Affinity DataIC50: 0.132nMAssay Description:The binding affinities of test compounds were determined by a radioligand competitive binding assay using 177Lu labeled C-1 as the reference radiolig...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50370752(CHEMBL1791384)
Affinity DataIC50: 0.140nMAssay Description:Displacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50048908(CHEMBL415788)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50240845(2-{(S)-2-[2-({(S)-1-[(S)-2-((S)-2-Amino-5-guanidin...)
Affinity DataKi:  0.140nMAssay Description:Binding affinity to human NTR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50366427(CHEMBL1793865)
Affinity DataKi:  0.150nMAssay Description:Compound was tested in vitro for its binding affinity against Neurotensin Receptor after peripheral administrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50048908(CHEMBL415788)
Affinity DataEC50:  0.150nMAssay Description:Agonist activity at human NTS1 expressed in HEK293 cells co-expressing Galphaq/RlucII/GFP10-Ggamma1/Gbeta1 assessed as increase in Galphaq activation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50240845(2-{(S)-2-[2-({(S)-1-[(S)-2-((S)-2-Amino-5-guanidin...)
Affinity DataKd:  0.160nMAssay Description:In vitro inhibition of [3H]-NT binding to human striatal Neurotensin receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50130880(pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-L...)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of human NTR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNeurotensin receptor type 1(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50130880(pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-L...)
Affinity DataKi:  0.170nMAssay Description:Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50370753(CHEMBL1791383)
Affinity DataIC50: 0.180nMAssay Description:Displacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50048908(CHEMBL415788)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50130880(pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-L...)
Affinity DataIC50: 0.200nMAssay Description:Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM693824(US20240287046, Compound I-7)
Affinity DataIC50: 0.206nMAssay Description:The binding affinities of test compounds were determined by a radioligand competitive binding assay using 177Lu labeled C-1 as the reference radiolig...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetNeurotensin receptor type 1(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50281784(Ac-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH ...)
Affinity DataKi:  0.210nMAssay Description:Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM693822(US20240287046, Compound I-5)
Affinity DataIC50: 0.220nMAssay Description:The binding affinities of test compounds were determined by a radioligand competitive binding assay using 177Lu labeled C-1 as the reference radiolig...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50502374(CHEMBL4593174)
Affinity DataKi:  0.223nMAssay Description:Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50342238((S)-2-((2S,3S)-2-((S)-2-((S)-1-((S)-2-((S)-3-amino...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50130880(pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-L...)
Affinity DataEC50:  0.230nMAssay Description:Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50342239((S)-2-((2S,3S)-2-((S)-2-((S)-1-((S)-2-((S)-2-amino...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50048908(CHEMBL415788)
Affinity DataKi:  0.240nMAssay Description:Binding affinity to human neurotensin receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50133195(Compound KK10 | CHEMBL133340)
Affinity DataIC50: 0.240nMAssay Description:Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50048908(CHEMBL415788)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2018
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50048908(CHEMBL415788)
Affinity DataKi:  0.240nMAssay Description:Binding affinity to human NTS1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50130880(pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-L...)
Affinity DataIC50: 0.240nMAssay Description:Binding affinity to NTS1 receptor (unknown origin) by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50553767(CHEMBL4789659)
Affinity DataEC50:  0.240nMAssay Description:Agonist activity at human NTS1 expressed in HEK293 cells co-expressing Galphaq/RlucII/GFP10-Ggamma1/Gbeta1 assessed as increase in Galphaq activation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50440738(CHEMBL2431105)
Affinity DataIC50: 0.240nMAssay Description:Displacement of [125I]-neurotensin from NTR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50440738(CHEMBL2431105)
Affinity DataIC50: 0.240nMAssay Description:Displacement of [125I]-neurotensin from NTR1 in HUVEC after 1 hr by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
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