Compile Data Set for Download or QSAR
Report error Found 446 Enz. Inhib. hit(s) with Target = 'P2Y purinoceptor 6'
TargetP2Y purinoceptor 6(Mouse)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50608213(CHEMBL5274126)
Affinity DataEC50:  1nMAssay Description:Agonist activity at P2Y6R in mouse adipose tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50421161(CHEMBL2086761)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human GFP-tagged P2Y6 receptor expressed in human 1321N1 cells assessed as intracellular calcium mobilization by fura2/AM-based f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50496863(CHEMBL3220052)
Affinity DataEC50:  9nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50496853(CHEMBL1198754)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50319139(P1-Uridine5'-P3-Cyclohexyltriphosphate Triethylamm...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50118239(uridine 5'-(trihydrogen diphosphate) | UDP | Uridi...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50306710(CHEMBL1094759 | CHEMBL590494 | ((2R,3S,4R,5R)-3,4-...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as calcium elevation by fura2/AM assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50306710(CHEMBL1094759 | CHEMBL590494 | ((2R,3S,4R,5R)-3,4-...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at P2Y6 receptor expressed in human 1321N1 cells assessed as inositol phosphate accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50306710(CHEMBL1094759 | CHEMBL590494 | ((2R,3S,4R,5R)-3,4-...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50403871(URIDINE_DIPHOSPHATE)
Affinity DataEC50:  15nMAssay Description:Agonist activity at P2Y6 receptor expressed in human 1321N1 cells assessed as inositol phosphate accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50194152((2R,3R,4S,5R)-1-(3,4-dihydroxy-5-(diphosphoryloxym...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50403871(URIDINE_DIPHOSPHATE)
Affinity DataEC50:  15nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 6 (hP2Y6) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50496856(CHEMBL3220047)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50013029(CHEMBL3261378)
Affinity DataEC50:  23nMAssay Description:Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as stimulation of [3H]inositol phosphate accumulation by liquid scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50496854(CHEMBL1198872)
Affinity DataEC50:  26nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50421169(CHEMBL2086770)
Affinity DataEC50:  28nMAssay Description:Agonist activity at human P2Y6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50496855(CHEMBL3220048)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50454137(CHEMBL1321988)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced inositol-1-phosphate accumulation pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50454137(CHEMBL1321988)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization incubated for 5 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50454137(CHEMBL1321988)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at human P2Y6More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50454137(CHEMBL1321988)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at P2Y6 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50496857(CHEMBL3220046)
Affinity DataEC50:  39nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50496858(CHEMBL3220050)
Affinity DataEC50:  41nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50118239(uridine 5'-(trihydrogen diphosphate) | UDP | Uridi...)
Affinity DataEC50:  42nMAssay Description:Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50303353(CHEMBL1086489 | CHEMBL567321 | Triethylazanium ({[...)
Affinity DataEC50:  42nMAssay Description:Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating Gq protein assessed as [3H]inositol p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50118239(uridine 5'-(trihydrogen diphosphate) | UDP | Uridi...)
Affinity DataEC50:  42nMAssay Description:Agonist activity at human P2Y6R expressed in 1321N1 cells assessed as calcium mobilization measured by microplate reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50303353(CHEMBL1086489 | CHEMBL567321 | Triethylazanium ({[...)
Affinity DataEC50:  42nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50306709(O-{[(2R,3S,4R,5R)-5-(5-bromo-2,4-dioxo-3,4-dihydro...)
Affinity DataEC50:  47nMAssay Description:Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as calcium elevation by fura2/AM assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50403871(URIDINE_DIPHOSPHATE)
Affinity DataEC50:  47nMAssay Description:Agonist activity at human P2Y6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50118239(uridine 5'-(trihydrogen diphosphate) | UDP | Uridi...)
Affinity DataEC50:  48nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50306710(CHEMBL1094759 | CHEMBL590494 | ((2R,3S,4R,5R)-3,4-...)
Affinity DataEC50:  49nMAssay Description:Agonist activity at human P2Y6R expressed in 1321N1 cells assessed as calcium mobilization measured by microplate reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50319142(5-Iodouridine5'-Methylenediphosphate Triethylammon...)
Affinity DataEC50:  49nMAssay Description:Agonist activity at human P2Y6R expressed in 1321N1 cells assessed as calcium mobilization measured by microplate reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50421165(CHEMBL2086765)
Affinity DataEC50:  60nMAssay Description:Agonist activity at human GFP-tagged P2Y6 receptor expressed in human 1321N1 cells assessed as intracellular calcium mobilization by fura2/AM-based f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50194160(CHEMBL216011 | (2R,3R,4S,5R)-1-(3,4-dihydroxy-5-(d...)
Affinity DataEC50:  60nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50319130(((((2R,3S,4R,5R)-3,4-dihydroxy-5-((E)-4-(methoxyim...)
Affinity DataEC50:  63nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50319129(CHEMBL1204010 | CHEMBL1084020 | N4-Methoxycytidine...)
Affinity DataEC50:  70nMAssay Description:Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating Gq protein assessed as [3H]inositol p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50199191(((2R,3S,4R,5R)-5-(2,4-dioxo-3-(2-oxo-2-phenylethyl...)
Affinity DataEC50:  70nMAssay Description:Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50199191(((2R,3S,4R,5R)-5-(2,4-dioxo-3-(2-oxo-2-phenylethyl...)
Affinity DataEC50:  70nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50319143(CHEMBL1083764 | CHEMBL1198849 | N4-Methoxycytidine...)
Affinity DataEC50:  80nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50194147(4-Thio-UDP | [(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-oxo...)
Affinity DataEC50:  80nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50306706(((2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methoxy-2,4-diox...)
Affinity DataEC50:  80nMAssay Description:Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as calcium elevation by fura2/AM assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50118239(uridine 5'-(trihydrogen diphosphate) | UDP | Uridi...)
Affinity DataEC50:  86nMAssay Description:Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50012975(CHEMBL3261366)
Affinity DataEC50:  90nMAssay Description:Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as stimulation of [3H]inositol phosphate accumulation by liquid scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50013012(CHEMBL3261374)
Affinity DataEC50:  90nMAssay Description:Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as stimulation of [3H]inositol phosphate accumulation by liquid scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50523545(CHEMBL4538320)
Affinity DataEC50:  97nMAssay Description:Agonist activity at human P2Y6R expressed in 1321N1 cells assessed as calcium mobilization measured by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50523545(CHEMBL4538320)
Affinity DataEC50:  97nMAssay Description:Agonist activity at human P2Y6R expressed in 1321N1 cells assessed as calcium mobilization measured by microplate reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50454137(CHEMBL1321988)
Affinity DataIC50: 98nMAssay Description:Antagonist activity at rat P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced inositol-1-phosphate accumulation prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50403871(URIDINE_DIPHOSPHATE)
Affinity DataEC50:  100nMAssay Description:Agonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y6 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50614412(CHEMBL5272895)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human P2Y6More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetP2Y purinoceptor 6(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50496862(CHEMBL3220051)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
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