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Report error Found 1009 Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily KQT member 2'
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50442471(CHEMBL2440363)
Affinity DataEC50:  0.900nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50442470(CHEMBL401942)
Affinity DataEC50:  2.40nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM557812(US11365181, Compound 03058)
Affinity DataEC50:  8nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50410081(CHEMBL361184)
Affinity DataEC50:  10nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50420073(CHEMBL2047506)
Affinity DataEC50:  10nMAssay Description:Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50410081(CHEMBL361184)
Affinity DataEC50:  10nMAssay Description:Effect on outward potassium currents in whole-cell patch clamp assay of HEK 293 cells expressing cloned mouse KCNQ2 channel at -40 mVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50592356(CHEMBL4458793)
Affinity DataEC50:  18nMAssay Description:Agonist activity at Kv7.2/3 (unknown origin) expressed in CHO cells co-expressing GFPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50410077(CHEMBL180886)
Affinity DataEC50:  20nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM50463349(CHEMBL4250878)
Affinity DataEC50:  20nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM697196(US20240316020, Example 11 | 1-[[2- (difluoromethox...)
Affinity DataEC50:  20nMAssay Description:Human Kv7.2, Kv7.4 or Kv7.5/7.3 channels were evaluated using a voltage protocol in which cells were voltage-clamped at a holding potential of -60 mV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50410077(CHEMBL180886)
Affinity DataEC50:  20nMAssay Description:Effect on outward potassium currents in whole-cell patch clamp assay of HEK 293 cells expressing cloned mouse KCNQ2 channel at -40 mVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM697189(US20240316020, Example 4 | 1-[[2- (difluoromethoxy...)
Affinity DataEC50:  20nMAssay Description:Human Kv7.2, Kv7.4 or Kv7.5/7.3 channels were evaluated using a voltage protocol in which cells were voltage-clamped at a holding potential of -60 mV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

LigandPNGBDBM50465779(CHEMBL4278049)
Affinity DataEC50:  20nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM697190(US20240316020, Example 5 | 1-[[2-(2,2- difluoropro...)
Affinity DataEC50:  20nMAssay Description:Human Kv7.2, Kv7.4 or Kv7.5/7.3 channels were evaluated using a voltage protocol in which cells were voltage-clamped at a holding potential of -60 mV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM50463341(CHEMBL4238783)
Affinity DataEC50:  20nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50415511(CHEMBL598553)
Affinity DataEC50:  21nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM557809(US11365181, Compound 03043)
Affinity DataEC50:  23nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM50415531(CHEMBL592297)
Affinity DataEC50:  23nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50121052(CHEMBL3621438)
Affinity DataEC50:  24nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
LigandPNGBDBM50415509(CHEMBL599164)
Affinity DataEC50:  25nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50415502(CHEMBL598126)
Affinity DataEC50:  27nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50415507(CHEMBL604937)
Affinity DataEC50:  28nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50415516(CHEMBL599374)
Affinity DataEC50:  28nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50415529(CHEMBL589898)
Affinity DataEC50:  29nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM50463346(CHEMBL4250403)
Affinity DataEC50:  30nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50420077(CHEMBL2047511)
Affinity DataEC50:  30nMAssay Description:Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM50463345(CHEMBL4247074)
Affinity DataEC50:  34nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50254401(CHEMBL4093377)
Affinity DataEC50:  37nMAssay Description:Activation of KCNQ2/3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Rat)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50601513(CHEMBL5180351)
Affinity DataEC50:  37nMAssay Description:Agonist activity at rat KCNQ2 channel expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataEC50:  37nMAssay Description:Activation of KCNQ2/3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM50120996(CHEMBL3621449)
Affinity DataEC50:  40nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM50463342(CHEMBL4247002)
Affinity DataEC50:  40nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50465781(CHEMBL4276984)
Affinity DataEC50:  40nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50465775(CHEMBL1703636)
Affinity DataEC50:  40nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50415521(CHEMBL609624)
Affinity DataEC50:  44nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50415526(CHEMBL591302)
Affinity DataEC50:  44nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM50529214(CHEMBL343822)
Affinity DataIC50: 48nMAssay Description:Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50415520(CHEMBL599376)
Affinity DataEC50:  49nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM557815(US11365181, Compound 03066)
Affinity DataEC50:  49nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM700206(US20240336571, Example 47 | 1-[[2- (difluoromethox...)
Affinity DataEC50:  50nMAssay Description:At the beginning of each assay, 20 μl of cell suspension was dispensed into each well of a multi-hole 384-well SyncroPatch chip by the onboard p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
US Patent

LigandPNGBDBM50513737(CHEMBL4549421)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50513734(CHEMBL4516269)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50121053(CHEMBL3621439)
Affinity DataEC50:  50nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM697192(US20240316020, Example 7 | 1-[[2- (cyclopropylmeth...)
Affinity DataEC50:  50nMAssay Description:Human Kv7.2, Kv7.4 or Kv7.5/7.3 channels were evaluated using a voltage protocol in which cells were voltage-clamped at a holding potential of -60 mV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

LigandPNGBDBM50465773(CHEMBL4277250)
Affinity DataEC50:  50nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM50592357(CHEMBL5185685)
Affinity DataEC50:  50nMAssay Description:Agonist activity at Kv7.2 (unknown origin) assessed as shifting of voltage dependent activation to more negative potentials by SyncroPatch assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM50415506(CHEMBL599781)
Affinity DataEC50:  53nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM50529215(CHEMBL342375 | CHEBI:35046)
Affinity DataIC50: 55nMAssay Description:Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM557810(US11365181, Compound 03044)
Affinity DataEC50:  57nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50143560(N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4...)
Affinity DataEC50:  60nMAssay Description:Effect on outward potassium currents in whole-cell patch clamp assay of HEK 293 cells expressing cloned mouse KCNQ2 channel at -40 mVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
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