Compile Data Set for Download or QSAR
Report error Found 1736 Enz. Inhib. hit(s) with Target = 'Protein cereblon'
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50586185(CHEMBL5090416)
Affinity DataIC50: 0.0200nMAssay Description:Binding affinity to CRBN (unknown origin) measured by Fluorescent Polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50586179(CHEMBL4744617)
Affinity DataIC50: 0.310nMAssay Description:Binding affinity to CRBN (unknown origin) measured by Fluorescent Polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50586184(CHEMBL5078429)
Affinity DataIC50: 0.450nMAssay Description:Binding affinity to CRBN (unknown origin) measured by Fluorescent Polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50630767(CHEMBL5279477)
Affinity DataIC50: 0.880nMAssay Description:Inhibition of CRBN (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50643720(CHEMBL5574408)
Affinity DataIC50: 0.900nMAssay Description:Binding affinity to GST-tagged human CRBN by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594639(Methyl 6-(6,8-dioxo-2,7-diazaspiro[4.5]decan-2-yl)...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM693802(3-(5-(((1S,2S)-2-(3-((cis)-4- isopropoxycyclohexyl...)
Affinity DataEC50:  1nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM562168(US11401256, Example 60 | 6-(3,4-Dihydro-2H-quinoli...)
Affinity DataKd:  1nMAssay Description:Process 1) Optimization of measurement parameters to minimize protein consumption and to minimize the dilution effect and the DMSO content 2) Titrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594669(2-Benzoyl-2,7-diazaspiro[4.5]decane-6,8-dione | US...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM693805(3-(5-(((1S,2S)-2-(3-(4- ethoxycyclohexyl)azetidin-...)
Affinity DataEC50:  1nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594668(2-(1-Acetylindoline-4-carbonyl)-2,7-diazaspiro[4.5...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594700(8-(Pyrazolo[1,5-a]pyridine-3-carbonyl)-1,3,8-triaz...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594643((+)-2-(4-Nitrophenyl)-2,7-diazaspiro[4.5]decane-6,...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594705(8-(4-Nitrophenyl)-1,3,8-triazaspiro[4.5]decane-2,4...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594640(2-(Thiazolo[4,5-b]pyridin-2-yl)-2,7-diazaspiro[4.5...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594672(2-(5-Aminopyridin-2-yl-2,7-diazaspiro[4.5]decane-6...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594678(2-(Pyrazolo[1,5-a]pyridine-3-carbonyl)-2,7-diazasp...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594645(2-(Benzo[d]thiazol-2-yl)-2,7-diazaspiro[4.5]decane...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594708(8-Benzoyl-2,8-diazaspiro[4.5]decane-1,3-dione | US...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM693807(3-(5-(((1S,2S)-2-(3-(4- (difluoromethoxy)cyclohexy...)
Affinity DataEC50:  1nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594663(2-(5-Nitropyridin-2-yl)-2,7-diazaspiro[4.5]decane-...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594662(2-(Benzo[d]thiazole-5-carbonyl)-2,7-diazaspiro[4.5...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594699(8-(Benzofuran-3-carbonyl)-1,3,8-triazaspiro[4.5]de...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594666(2-(5-Nitro-1H-benzo[d]imidazol-2-yl)-2,7-diazaspir...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594665(Methyl 6-(6,8-dioxo-2,7-diazaspiro[4.5]decan-2-yl)...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50586180(CHEMBL5082689)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity to CRBN (unknown origin) measured by Fluorescent Polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50630767(CHEMBL5279477)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of N-terminal fused Nano Luc CRBN in HEK293T cells by NanoBRET CRBN engagement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50630767(CHEMBL5279477)
Affinity DataIC50: 1.10nMAssay Description:Displacement of BODIPY-lenalidomide from human N-terminal NanoLuc-fused CRBN expressed in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50643726(CHEMBL5566094)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity to GST-tagged human CRBN by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50643725(CHEMBL5575548)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity to GST-tagged human CRBN by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50643724(CHEMBL5565362)
Affinity DataIC50: 1.30nMAssay Description:Binding affinity to GST-tagged human CRBN by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50643721(CHEMBL5575700)
Affinity DataIC50: 1.30nMAssay Description:Binding affinity to GST-tagged human CRBN by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50634837(CHEMBL5437141)
Affinity DataIC50: 1.5nMAssay Description:Binding affinity to human androgen receptor transfected in HEK293 cell membrane co-transfected with ARC1 assessed as inhibition of [3H]-methyltrienol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50586176(CHEMBL4742130)
Affinity DataIC50: 1.60nMAssay Description:Binding affinity to CRBN (unknown origin) measured by Fluorescent Polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50643722(CHEMBL5564627)
Affinity DataIC50: 1.80nMAssay Description:Binding affinity to GST-tagged human CRBN by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM693802(3-(5-(((1S,2S)-2-(3-((cis)-4- isopropoxycyclohexyl...)
Affinity DataEC50:  2nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594704(8-(Benzo[d]thiazol-2-yl)-2,8-diazaspiro[4.5]decane...)
Affinity DataKd:  2nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50: 2nMAssay Description:Binding affinity to cereblon in human RV4:11 cells expressing wild type p53 assessed as cell growth inhibition measured after 4 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM669519(US20240132463, Compound 1 | N-(2-(2,6-dioxopiperid...)
Affinity DataIC50: 2nMAssay Description:In this competitive fluorescent polarization assay Cy5 conjugated lenalidomide analog (Cy5-O-Len)13 was used as a fluorescent probe. 6×His-CRBN-DDB1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM686544(US20240246935, Example 124 | 3-(5-(((1S,2S)-2-(3-(...)
Affinity DataEC50:  2nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM693789(3-(5-(((1S,2S)-2-(3-(4,4- difluorocyclohexyl)azeti...)
Affinity DataEC50:  2nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594658(US11584748, Example 25 | US11584748, Example 56 | ...)
Affinity DataKd:  2nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594657(tert-Butyl 6-(6,8-dioxo-2,7-diazaspiro[4.5]decan-2...)
Affinity DataKd:  2nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594658(US11584748, Example 25 | US11584748, Example 56 | ...)
Affinity DataKd:  2nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594694(8-(Benzo[d]thiazol-2-yl)-1,3,8-triazaspiro[4.5]dec...)
Affinity DataKd:  2nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594693(8-Benzoyl-1,3,8-triazaspiro[4.5]decane-2,4-dione |...)
Affinity DataKd:  2nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM562157(US11401256, Example 49 | N-Methyl-2-[3-(methylcarb...)
Affinity DataKd:  2nMAssay Description:Process 1) Optimization of measurement parameters to minimize protein consumption and to minimize the dilution effect and the DMSO content 2) Titrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM693795(US20240287037, Example 9 | US20240287037, Example ...)
Affinity DataEC50:  2nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM693793(US20240287037, Example 7 | 3-(5-(((1S,2S)-2-(3-((c...)
Affinity DataEC50:  2nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50643723(CHEMBL5575710)
Affinity DataIC50: 2.80nMAssay Description:Binding affinity to GST-tagged human CRBN by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
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