Compile Data Set for Download or QSAR
Report error Found 1786 Enz. Inhib. hit(s) with Target = 'Receptor-interacting serine/threonine-protein kinase 2'
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50537138(CHEMBL4531690)
Affinity DataIC50: 0.0110nMAssay Description:Displacement of fluorescent tracer from N-terminus of human RIPK2 expressed in HEK293T cells after 2 hrs by NanoBRET target engagement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50574936(CHEMBL4857880)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of full length His-tagged RIPK2 (unknown origin) expressed in baculovirus expression system using fluorescent labelled ATP competitive lig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50574935(CHEMBL4866182)
Affinity DataIC50: 0.158nMAssay Description:Inhibition of full length His-tagged RIPK2 (unknown origin) expressed in baculovirus expression system using fluorescent labelled ATP competitive lig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50597348(CHEMBL5177284)
Affinity DataKd:  0.280nMAssay Description:Binding affinity to human RIPK2 in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50597348(CHEMBL5177284)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of full length FLAG His-tagged RIPK2 (unknown origin) expressed in Baculovirus by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50597348(CHEMBL5177284)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of RIPK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303361(US10138222, Example 76)
Affinity DataIC50: 0.610nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50405272(BDBM50516678 | CHEMBL4596287)
Affinity DataKd:  0.780nMAssay Description:Binding affinity to RIPK2 (unknown origin) assessed as dissociation constant by kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50597341(CHEMBL5187454)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human RIPK2 incubated for 120 mins in presence of [gamma33P]ATP by scintillation counting based radiometry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303364(BDBM303369 | US10138222, Example 79)
Affinity DataIC50: 0.810nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303360(US10138222, Example 75)
Affinity DataIC50: 0.900nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303438(US10138222, Example 166)
Affinity DataIC50: 0.940nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303440(US10138222, Example 168)
Affinity DataIC50: 0.950nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303823(US10138241, Example 7 | US11130754, Example 7 | US...)
Affinity DataIC50: 0.990nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303823(US10138241, Example 7 | US11130754, Example 7 | US...)
Affinity DataIC50: 0.990nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303823(US10138241, Example 7 | US11130754, Example 7 | US...)
Affinity DataIC50: 0.990nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303380(US10138222, Example 105)
Affinity DataIC50: 1nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303439(US10138222, Example 167)
Affinity DataIC50: 1nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human His-tagged RIPK2 (8 to 317 residues) incubated for 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303359(US10138222, Example 74)
Affinity DataIC50: 1nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303362(US10138222, Example 77)
Affinity DataIC50: 1.10nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303432(US10138222, Example 160)
Affinity DataIC50: 1.10nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303435(US10138222, Example 163)
Affinity DataIC50: 1.10nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303355(US10138222, Example 68)
Affinity DataIC50: 1.10nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303909(N-Cyclopropyl-5-{1-[7-ethoxy-6-(4-fluoro-1-methyl-...)
Affinity DataIC50: 1.10nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303909(N-Cyclopropyl-5-{1-[7-ethoxy-6-(4-fluoro-1-methyl-...)
Affinity DataIC50: 1.10nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303909(N-Cyclopropyl-5-{1-[7-ethoxy-6-(4-fluoro-1-methyl-...)
Affinity DataIC50: 1.10nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303437(US10138222, Example 165)
Affinity DataIC50: 1.20nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303859(US10138241, Example 45 | US11130754, Example 45 | ...)
Affinity DataIC50: 1.20nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303859(US10138241, Example 45 | US11130754, Example 45 | ...)
Affinity DataIC50: 1.20nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303849(US10138241, Example 35 | US11130754, Example 35 | ...)
Affinity DataIC50: 1.20nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303849(US10138241, Example 35 | US11130754, Example 35 | ...)
Affinity DataIC50: 1.20nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303849(US10138241, Example 35 | US11130754, Example 35 | ...)
Affinity DataIC50: 1.20nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303859(US10138241, Example 45 | US11130754, Example 45 | ...)
Affinity DataIC50: 1.20nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303430(US10138222, Example 158)
Affinity DataIC50: 1.20nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303363(US10138222, Example 78)
Affinity DataIC50: 1.30nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303914(N-Cyclopropyl-5-{1-[6-(1-ethyl-4-fluoro-piperidin-...)
Affinity DataIC50: 1.30nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50467984(CHEMBL4293287)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of full length His/flag-tagged RIPK2 (unknown origin) expressed in baculovirus expression system using fluorescently labeled substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303826(US10138241, Example 10 | US11130754, Example 10 | ...)
Affinity DataIC50: 1.30nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303826(US10138241, Example 10 | US11130754, Example 10 | ...)
Affinity DataIC50: 1.30nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303441(US10138222, Example 169)
Affinity DataIC50: 1.30nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303826(US10138241, Example 10 | US11130754, Example 10 | ...)
Affinity DataIC50: 1.30nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303914(N-Cyclopropyl-5-{1-[6-(1-ethyl-4-fluoro-piperidin-...)
Affinity DataIC50: 1.30nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303914(N-Cyclopropyl-5-{1-[6-(1-ethyl-4-fluoro-piperidin-...)
Affinity DataIC50: 1.30nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303364(BDBM303369 | US10138222, Example 79)
Affinity DataIC50: 1.40nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303887(US10138241, Example 75 | US11130754, Example 75 | ...)
Affinity DataIC50: 1.40nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303887(US10138241, Example 75 | US11130754, Example 75 | ...)
Affinity DataIC50: 1.40nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303887(US10138241, Example 75 | US11130754, Example 75 | ...)
Affinity DataIC50: 1.40nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303907(N-Cyclopropyl-2-fluoro-5-{1-[6-(4-fluoro-1-methylp...)
Affinity DataIC50: 1.40nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM303907(N-Cyclopropyl-2-fluoro-5-{1-[6-(4-fluoro-1-methylp...)
Affinity DataIC50: 1.40nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent

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