Compile Data Set for Download or QSAR
Report error Found 941 Enz. Inhib. hit(s) with Target = 'Ribosomal protein S6 kinase alpha-3'
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of human RSK2 using KKLNRTLSVA as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.124nMAssay Description:Inhibition of human RSK2 using KKLNRTLSVA as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168025(US9073926, 59)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of RSK2 (unknown origin) preincubated for 1 hr followed by substrate addition and measured after 1 hr by luciferase analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168025(US9073926, 59)
Affinity DataIC50: 0.200nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168034(US9073926, 68)
Affinity DataIC50: 0.270nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50467097(CHEMBL4292020)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of RSK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168027(US9073926, 61)
Affinity DataIC50: 0.340nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168012(US9073926, 46)
Affinity DataIC50: 0.390nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of RSK2 using biotinylated substrate preincubated for 15 mins before substrate addition measured after 30 mins by fluorescence microplate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50369721(CHEMBL3702836)
Affinity DataKd:  0.540nMAssay Description:Binding affinity to RPS6KA3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168006(US9073926, 40)
Affinity DataIC50: 0.780nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50: 1nMAssay Description:Inhibition of human RSK2 in MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50360293(CHEMBL1933280 | US9150577, 81)
Affinity DataIC50: 1nMAssay Description:Inhibition of human RSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50536679(CHEMBL4568087)
Affinity DataIC50: 1nMAssay Description:Inhibition of full-length recombinant human His-tagged RPS6KA3 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50: 1nMAssay Description:Inhibition of human RSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168009(US9073926, 43)
Affinity DataIC50: 1.10nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168001(US9073926, 35)
Affinity DataIC50: 1.60nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50431812(CHEMBL2347053)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of RSK2 (unknown origin) using AKRRRLSSLRA as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168070(US9073926, 104)
Affinity DataIC50: 1.60nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM286091(US10758530, Compound 18 | BDBM286094 | US10081632,...)
Affinity DataIC50: 1.70nMAssay Description:Radioisotope assays (SignalChem) were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM286091(US10758530, Compound 18 | BDBM286094 | US10081632,...)
Affinity DataIC50: 1.70nMAssay Description:Radioisotope assays were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radioactive workin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50360291(CHEMBL1933278 | US9150577, 114)
Affinity DataIC50: 2nMAssay Description:Inhibition of human RSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 2nMAssay Description:Inhibition of human RSK2 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-3 [399-740](Human)
University of California

US Patent
LigandPNGBDBM259863(US9505766, 68)
Affinity DataIC50: 2nMpH: 8.0 T: 2°CAssay Description:RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50467103(CHEMBL4289492)
Affinity DataIC50: 2nMAssay Description:Inhibition of RSK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  2nMAssay Description:Binding affinity to recombinant human full length N-terminal GST-tagged RPS6KA3 expressed in baculovirus expression system using S6K peptide as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50467096(CHEMBL4278817)
Affinity DataIC50: 2nMAssay Description:Inhibition of RSK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50360291(CHEMBL1933278 | US9150577, 114)
Affinity DataIC50: 2nMAssay Description:Inhibition of human RSK2 in MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM167995(US9073926, 29)
Affinity DataIC50: 2.10nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM167998(US9073926, 32)
Affinity DataIC50: 2.30nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM167992(US9073926, 26)
Affinity DataIC50: 2.30nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3 [399-740](Human)
University of California

US Patent
LigandPNGBDBM259840(US9505766, 44)
Affinity DataIC50: 2.40nMpH: 8.0 T: 2°CAssay Description:RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168051(US9073926, 85)
Affinity DataIC50: 2.60nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168028(US9073926, 62)
Affinity DataIC50: 3nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3 [399-740](Human)
University of California

US Patent
LigandPNGBDBM259876(US9505766, 81)
Affinity DataIC50: 3nMpH: 8.0 T: 2°CAssay Description:RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168030(US9073926, 64)
Affinity DataIC50: 3nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3 [399-740](Human)
University of California

US Patent
LigandPNGBDBM259807(US9505766, CN-NH2 (6))
Affinity DataIC50: 3nMpH: 8.0 T: 2°CAssay Description:RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50420996(CHEMBL2086760)
Affinity DataIC50: 3nMAssay Description:Inhibition of RSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168060(US9073926, 94)
Affinity DataIC50: 3.30nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168061(US9073926, 95)
Affinity DataIC50: 3.60nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3 [399-740](Human)
University of California

US Patent
LigandPNGBDBM259861(US9505766, 66)
Affinity DataIC50: 3.60nMpH: 8.0 T: 2°CAssay Description:RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  3.80nMAssay Description:Binding affinity to human RPS6KA3 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-3 [399-740](Human)
University of California

US Patent
LigandPNGBDBM259839(US9505766, 43)
Affinity DataIC50: 3.80nMpH: 8.0 T: 2°CAssay Description:RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168013(US9073926, 47)
Affinity DataIC50: 3.80nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168004(US9073926, 38)
Affinity DataIC50: 3.80nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168064(US9073926, 98)
Affinity DataIC50: 3.90nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM168032(US9073926, 66)
Affinity DataIC50: 4nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50403059(CHEMBL2216829 | US9505766, 64)
Affinity DataIC50: 4nMAssay Description:Inhibition of RSK2 transfected in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50111391(CHEMBL3604787)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant Histidine-tagged RSK2 using biotin-AGAGRSRHSSYPAGT-OH as substrate preincubated for 30 mins followed by ATP and subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50361851(CHEMBL1938803 | US9150577, 55)
Affinity DataIC50: 4nMAssay Description:Inhibition of RSK2 phosphorylation by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
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