Compile Data Set for Download or QSAR
Report error Found 326 Enz. Inhib. hit(s) with Target = 'Ribosomal protein S6 kinase alpha-6'
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.134nMAssay Description:Inhibition of human RSK4 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.159nMAssay Description:Inhibition of human RSK4 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM286091(US10758530, Compound 18 | BDBM286094 | US10081632,...)
Affinity DataIC50: 0.300nMAssay Description:Radioisotope assays (SignalChem) were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM286091(US10758530, Compound 18 | BDBM286094 | US10081632,...)
Affinity DataIC50: 0.300nMAssay Description:Radioisotope assays were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radioactive workin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human RSK4 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of RSK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50: 4nMAssay Description:Inhibition of RSK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50520159(CHEMBL4543618)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant full length human His6-tagged RSK4 expressed in baculovirus infected sf21 cells using biotin labelled Ahx-KKLNRTLSFAEPG pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM342166(US9771366, Compound 15 | (R)-1-benzyl-N-(9-methyl-...)
Affinity DataIC50: 8nMAssay Description:Radioisotope assays (SignalChem) were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM458758((R)-1-benzyl-N-(9-methyl-6-oxo-6,7,8,9-tetrahydrop...)
Affinity DataIC50: 8nMAssay Description:Radioisotope assays were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radioactive workin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50578032(CHEMBL4847762)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of RSK4 (unknown origin) incubated for 40 mins in presence of ATP and lipid substrate by Kinase-Glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50: 10nMAssay Description:Inhibition of RSK4 (14 to 702 residues) (unknown origin) using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK peptide as substrate incubated for 10 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50: 12nMAssay Description:Inhibition of RSK4 (unknown origin) incubated for 40 mins in presence of ATP and lipid substrate by Kinase-Glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50578046(CHEMBL4846725)
Affinity DataIC50: 12nMAssay Description:Inhibition of RSK4 (unknown origin) incubated for 40 mins in presence of ATP and lipid substrate by Kinase-Glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50578033(CHEMBL4847469)
Affinity DataIC50: 12nMAssay Description:Inhibition of RSK4 (unknown origin) incubated for 40 mins in presence of ATP and lipid substrate by Kinase-Glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  14nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-tagged RPS6KA6 (unknown origin) expressed in baculovirus infected Sf9 insect cells in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50: 15nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2008
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50: 15nMAssay Description:Inhibition of RSK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50578034(CHEMBL4870231)
Affinity DataIC50: 15nMAssay Description:Inhibition of RSK4 (unknown origin) incubated for 40 mins in presence of ATP and lipid substrate by Kinase-Glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50: 15nMAssay Description:Inhibition of RSK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50: 15nMAssay Description:Inhibition of RSK4 (unknown origin) using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK a substrate by [32P] gammaATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50578027(CHEMBL4870807)
Affinity DataIC50: 16nMAssay Description:Inhibition of RSK4 (unknown origin) incubated for 40 mins in presence of ATP and lipid substrate by Kinase-Glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  18nMAssay Description:Binding constant for RSK4(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  18nMAssay Description:Binding constant for RPS6KA6(Kin.Dom.1 - C-terminal) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50578040(CHEMBL4846978)
Affinity DataIC50: 18nMAssay Description:Inhibition of RSK4 (unknown origin) incubated for 40 mins in presence of ATP and lipid substrate by Kinase-Glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 19nMAssay Description:Inhibition of human Rsk4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  21nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-tagged RPS6KA6 (unknown origin) expressed in baculovirus infected Sf9 insect cells in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50128285(3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmet...)
Affinity DataKd:  25nMAssay Description:Binding constant for RSK4(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50578031(CHEMBL4845942)
Affinity DataIC50: 25nMAssay Description:Inhibition of RSK4 (unknown origin) incubated for 40 mins in presence of ATP and lipid substrate by Kinase-Glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  27nMAssay Description:Binding constant for RSK4(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50578035(CHEMBL4872665)
Affinity DataIC50: 29nMAssay Description:Inhibition of RSK4 (unknown origin) incubated for 40 mins in presence of ATP and lipid substrate by Kinase-Glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50578043(CHEMBL4852908)
Affinity DataIC50: 33nMAssay Description:Inhibition of RSK4 (unknown origin) incubated for 40 mins in presence of ATP and lipid substrate by Kinase-Glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 37nMAssay Description:Inhibition of RSK4 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human RPS6KA6 using KKLNRTLSVA as substrate in presence of [gamma33P]-ATP by HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50578036(CHEMBL4850890)
Affinity DataIC50: 55nMAssay Description:Inhibition of RSK4 (unknown origin) incubated for 40 mins in presence of ATP and lipid substrate by Kinase-Glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50578029(CHEMBL4856762)
Affinity DataIC50: 84nMAssay Description:Inhibition of RSK4 (unknown origin) incubated for 40 mins in presence of ATP and lipid substrate by Kinase-Glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  110nMAssay Description:Binding affinity to RPS6KA6(Kin.Dom.1-N-terminal)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  110nMAssay Description:Binding constant for RSK4(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50578024(CHEMBL4869608)
Affinity DataIC50: 117nMAssay Description:Inhibition of RSK4 (unknown origin) incubated for 40 mins in presence of ATP and lipid substrate by Kinase-Glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataKd:  150nMAssay Description:Binding constant for RSK4(Kin.Dom.2-C-terminal) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  160nMAssay Description:Binding constant for RSK4(Kin.Dom.2-C-terminal) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50520148(CHEMBL4538751 | US10894784, Example 30.03.01.A)
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant full length human His6-tagged RSK4 expressed in baculovirus infected sf21 cells using biotin labelled Ahx-KKLNRTLSFAEPG pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50520152(CHEMBL4594167 | US10894784, Example 150.02)
Affinity DataIC50: 177nMAssay Description:Inhibition of recombinant full length human His6-tagged RSK4 expressed in baculovirus infected sf21 cells using biotin labelled Ahx-KKLNRTLSFAEPG pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50520150(CHEMBL4566796)
Affinity DataIC50: 192nMAssay Description:Inhibition of recombinant full length human His6-tagged RSK4 expressed in baculovirus infected sf21 cells using biotin labelled Ahx-KKLNRTLSFAEPG pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd:  230nMAssay Description:Binding constant for RSK4(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd:  240nMAssay Description:Binding constant for RSK4(Kin.Dom.2-C-terminal) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd:  240nMAssay Description:Binding constant for RPS6KA6(Kin.Dom.2 - N-terminal) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM13336(4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]...)
Affinity DataKd:  250nMAssay Description:Binding constant for RPS6KA6(Kin.Dom.2 - N-terminal) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM13336(4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]...)
Affinity DataKd:  250nMAssay Description:Binding constant for RSK4(Kin.Dom.2-C-terminal) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM13531(4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-...)
Affinity DataKd:  270nMAssay Description:Binding constant for RPS6KA6(Kin.Dom.2 - N-terminal) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
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