Compile Data Set for Download or QSAR
Report error Found 140 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase ULK2'
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  0.790nMAssay Description:Binding constant for ULK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50503137(CHEMBL4516990)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of ULK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50612793(CHEMBL5266681)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of ULK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50111572(CHEMBL3605057)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of GST-tagged ULK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50503137(CHEMBL4516990)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of ULK2 (unknown origin) after 5 mins in presence of gamma-[32]P-ATP by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50503137(CHEMBL4516990)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human ULK2 by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human ULK2 using myelin basic protein as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  1.80nMAssay Description:Binding constant for ULK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50612791(CHEMBL5280560)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of ULK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50637636(CHEMBL5568152)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human ULK2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human ULK2 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human ULK2 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to ULK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM379177(US10266549, Example 88 | US10266549, Example 171a ...)
Affinity DataIC50: 11nMAssay Description:Inhibition of ULK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50111577(CHEMBL3605055)
Affinity DataIC50: 13nMAssay Description:Inhibition of SUMO-tagged ULK2 (unknown origin) kinase domain expressed in KRX cells using [32P]-gamma-ATP and myelin basic protein substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  13nMAssay Description:Binding constant for ULK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  13nMAssay Description:Binding affinity to ULK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542 |...)
Affinity DataKd:  19nMAssay Description:Binding constant for ULK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50637406(CHEMBL4744680)
Affinity DataIC50: 30nMAssay Description:Inhibition of human ULK2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50612792(CHEMBL5269042)
Affinity DataIC50: 30nMAssay Description:Inhibition of ULK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  30nMAssay Description:Binding affinity to recombinant N-terminal His-FLAG-GST-tagged ULK2 (unknown origin) (1 to 478 residues) expressed in baculovirus infected Sf9 insect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50637406(CHEMBL4744680)
Affinity DataIC50: 30nMAssay Description:Inhibition of human ULK2 by discoverX kinome scan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  35nMAssay Description:Binding affinity to ULK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50271370(CHEMBL4127042)
Affinity DataIC50: 38nMAssay Description:Inhibition of GST-tagged ULK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50612794(CHEMBL5288376)
Affinity DataIC50: 38nMAssay Description:Inhibition of ULK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50556418(CHEMBL4784530)
Affinity DataIC50: 38nMAssay Description:Inhibition of ULK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50111572(CHEMBL3605057)
Affinity DataIC50: 38nMAssay Description:Inhibition of ULK2 (unknown origin) after 5 mins in presence of gamma-[32]P-ATP by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataIC50: 42nMAssay Description:Inhibition of ULK2 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM722679(US20250059194, Example Table 1.3)
Affinity DataIC50: 50nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM722687(US20250059194, Example Table 1.11)
Affinity DataIC50: 50nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  54nMAssay Description:Binding constant for ULK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  60nMAssay Description:Binding affinity to ULK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  60nMAssay Description:Binding constant for ULK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  61nMAssay Description:Binding affinity to recombinant N-terminal His-FLAG-GST-tagged ULK2 (unknown origin) (1 to 478 residues) expressed in baculovirus infected Sf9 insect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  65nMAssay Description:Binding constant for ULK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataKd:  79nMAssay Description:Binding constant for ULK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM722682(US20250059194, Example Table 1.6)
Affinity DataIC50: 100nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  130nMAssay Description:Binding constant for ULK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataKd:  190nMAssay Description:Binding constant for ULK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50111575(CHEMBL3603853)
Affinity DataIC50: 200nMAssay Description:Inhibition of SUMO-tagged ULK2 (unknown origin) kinase domain expressed in KRX cells using [32P]-gamma-ATP and myelin basic protein substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM379177(US10266549, Example 88 | US10266549, Example 171a ...)
Affinity DataIC50: 212nMAssay Description:Inhibition of human ULK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50111572(CHEMBL3605057)
Affinity DataIC50: 230nMAssay Description:Inhibition of SUMO-tagged ULK2 (unknown origin) kinase domain expressed in KRX cells using [32P]-gamma-ATP and myelin basic protein substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM17051(N-{3-[(5-iodo-4-{[3-(thiophen-2-ylformamido)propyl...)
Affinity DataIC50: 310nMAssay Description:Inhibition of SUMO-tagged ULK2 (unknown origin) kinase domain expressed in KRX cells using [32P]-gamma-ATP and myelin basic protein substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 320nMAssay Description:Inhibition of human wild type ULK2 using Casein as substrate preincubated for 2 hrs followed by ATP addition and measured every 2 mins for 2.5 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM722685(US20250059194, Example Table 1.9)
Affinity DataIC50: 325nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM722677(US20250059194, Example Table 1.1)
Affinity DataIC50: 325nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50111573(CHEMBL3605056)
Affinity DataIC50: 360nMAssay Description:Inhibition of SUMO-tagged ULK2 (unknown origin) kinase domain expressed in KRX cells using [32P]-gamma-ATP and myelin basic protein substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  360nMAssay Description:Binding constant for ULK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd:  380nMAssay Description:Binding constant for ULK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50355499(CHEMBL1908395 | CHEMBL1908842 | US20250129067, Com...)
Affinity DataKd:  450nMAssay Description:Binding constant for ULK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
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