Report error Found 52 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein phosphatase 5'
Affinity DataKd: 0.540nMAssay Description:Binding affinity to human PP5 extracted from Escherichia coli BL21 using immobilized CDC37 as substrate assessed as increase in PP5 binding to substr...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of PPP5C (unknown origin) phosphatase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of PP5 (unknown origin) using [3H]-phosphohistone as substrate by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of PPP5C (unknown origin) phosphatase domainMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Activation of PPP5C (unknown origin) TPR domainMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of PP5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Activation of recombinant human PP5 (16 to 499 residues) Escherichia coli BL21 (DE3) using pNPP incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human PPP5C (169 to 499 residues) expressed in Escherichia coli using [32P]-phosphohistone as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human PP5 using [3H]-phosphohistone as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Inhibition of PP5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of PP5 (unknown origin) using [3H]-phosphohistone as substrate by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 7.80nMAssay Description:Activation of recombinant human PP5 (16 to 499 residues) Escherichia coli BL21 (DE3) using pNPP incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of PP5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of PP5 (unknown origin) using [3H]-phosphohistone as substrate by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of GST-tagged human PP5 expressed in Escherichia coli BL21 (DE3) using NH2-EDASRMEEVD-COOH peptide as substrate preincubated for 15 mins f...More data for this Ligand-Target Pair
Affinity DataKd: 77nMpH: 7.4 T: 2°CAssay Description:All fluorescence polarization experiments were conducted in 384-well, black, low volume, round-bottomed plates (Corning) using a BioTeck Synergy 2 pl...More data for this Ligand-Target Pair
Affinity DataKd: 79nMpH: 7.4 T: 2°CAssay Description:All fluorescence polarization experiments were conducted in 384-well, black, low volume, round-bottomed plates (Corning) using a BioTeck Synergy 2 pl...More data for this Ligand-Target Pair
Affinity DataKd: 133nMpH: 7.4 T: 2°CAssay Description:All fluorescence polarization experiments were conducted in 384-well, black, low volume, round-bottomed plates (Corning) using a BioTeck Synergy 2 pl...More data for this Ligand-Target Pair
Affinity DataKd: 140nMpH: 7.4 T: 2°CAssay Description:All fluorescence polarization experiments were conducted in 384-well, black, low volume, round-bottomed plates (Corning) using a BioTeck Synergy 2 pl...More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of human PP5 using [3H]-phosphohistone as substrateMore data for this Ligand-Target Pair
Affinity DataKd: 420nMpH: 7.4 T: 2°CAssay Description:All fluorescence polarization experiments were conducted in 384-well, black, low volume, round-bottomed plates (Corning) using a BioTeck Synergy 2 pl...More data for this Ligand-Target Pair
Affinity DataKd: 426nMpH: 7.4 T: 2°CAssay Description:All fluorescence polarization experiments were conducted in 384-well, black, low volume, round-bottomed plates (Corning) using a BioTeck Synergy 2 pl...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of PP5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of PPP5C (unknown origin) phosphatase domain using phosphohistone as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of PPP5C (unknown origin) phosphatase domainMore data for this Ligand-Target Pair
Affinity DataKd: 811nMAssay Description:Binding affinity to His-tagged human PP5 phosphatase domain extracted from Escherichia coli BL21 assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PPP5C (unknown origin) phosphatase domainMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PPP5C (unknown origin) phosphatase domainMore data for this Ligand-Target Pair
Affinity DataKd: 1.06E+3nMpH: 7.4 T: 2°CAssay Description:All fluorescence polarization experiments were conducted in 384-well, black, low volume, round-bottomed plates (Corning) using a BioTeck Synergy 2 pl...More data for this Ligand-Target Pair
Affinity DataKd: 1.14E+3nMAssay Description:Binding affinity to full length His-tagged human PP5 extracted from Escherichia coli BL21 assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
Affinity DataKd: 1.55E+3nMpH: 7.4 T: 2°CAssay Description:All fluorescence polarization experiments were conducted in 384-well, black, low volume, round-bottomed plates (Corning) using a BioTeck Synergy 2 pl...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of MBP fused recombinant human PPP5C phosphatase domain expressed in Escherichia coli using DiFMUP as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of GST-tagged human PP5 expressed in Escherichia coli BL21 (DE3) using NH2-EDASRMEEVD-COOH peptide as substrate preincubated for 15 mins f...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of GST-tagged human PP5 expressed in Escherichia coli BL21 (DE3) using NH2-EDASRMEEVD-COOH peptide as substrate preincubated for 15 mins f...More data for this Ligand-Target Pair
TargetSerine/threonine-protein phosphatase 5(Rattus norvegicus)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 7.80E+3nMAssay Description:Binding affinity to rat PPP5C (428 to 430 residues) phosphatase domain expressed in Escherichia coli BL21-codonplus (DE3)-RIL cells using para-nitrop...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PP5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:All fluorescence polarization experiments were conducted in 384-well, black, low volume, round-bottomed plates (Corning) using a BioTeck Synergy 2 pl...More data for this Ligand-Target Pair
Affinity DataKd: 1.44E+4nMAssay Description:Competitive binding affinity to His-tagged human PP5 TPR domain extracted from Escherichia coli BL21 assessed as dissociation constant preincubated w...More data for this Ligand-Target Pair
Affinity DataKd: 1.66E+4nMAssay Description:Binding affinity to His-tagged human PP5 TPR domain extracted from Escherichia coli BL21 assessed as dissociation constant by biolayer interferometri...More data for this Ligand-Target Pair
Affinity DataIC50: 2.11E+4nMAssay Description:Inhibition of DDO-3733 preincubated human PP5 phosphatase domain extracted from Escherichia coli BL21 using pNPP as substrate incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 2.21E+4nMAssay Description:Inhibition of human PP5 phosphatase domain extracted from Escherichia coli BL21 using pNPP as substrate incubated for 30 mins by spectrophotometric a...More data for this Ligand-Target Pair
Affinity DataKd: 3.72E+4nMAssay Description:Binding affinity to PP5 K430A mutant (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of phosphatase activity of human PP5 using pNPP as a substrate after 10 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMpH: 7.0Assay Description:Inhibition of PP5 (unknown origin) using pNPP as substrate at pH 7 at 25 degC by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of phosphatase activity of human PP5 using pNPP as a substrate after 10 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of phosphatase activity of human PP5 using pNPP as a substrate after 10 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 5.28E+4nMAssay Description:Activation of His-tagged human PP5 extracted from Escherichia coli BL21 using pNPP as substrate assessed as increase in phosphatase activity incubate...More data for this Ligand-Target Pair
Affinity DataEC50: 7.76E+4nMAssay Description:Activation of PPP5C (unknown origin) TPR domainMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PP5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 1.35E+5nMAssay Description:Activation of PPP5C (unknown origin) TPR domainMore data for this Ligand-Target Pair
