Compile Data Set for Download or QSAR
Report error Found 165 Enz. Inhib. hit(s) with Target = 'Small conductance calcium-activated potassium channel protein 1'
LigandPNGBDBM50260153(Octadecapeptide venom | Apamin | CHEMBL525408)
Affinity DataKi:  0.00400nMAssay Description:Displacement of [125I]apamin from Wistar rat cortical apamin-sensitive siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50: 0.0120nMAssay Description:Displacement of [125I]apamin from rat brain SkCa channel after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2020
Entry Details Article
PubMed
LigandPNGBDBM50155248(CHEMBL3774478)
Affinity DataIC50: 0.0160nMAssay Description:Displacement of [125I]apamin from rat cerebral cortex small conductance calcium-activated potassium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
LigandPNGBDBM50260153(Octadecapeptide venom | Apamin | CHEMBL525408)
Affinity DataIC50: 0.0240nMAssay Description:Inhibition of rat SK Calcium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandPNGBDBM50092131(CHEMBL612120 | UCL-1848 | CHEMBL420873 | 1,7-diazo...)
Affinity DataIC50: 1nMAssay Description:Inhibition of hSK1 calcium activated potassium channel (SKCa channel); Range is 1-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50092131(CHEMBL612120 | UCL-1848 | CHEMBL420873 | 1,7-diazo...)
Affinity DataIC50: 2nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50061977(CHEMBL117908 | 17,25-diazonia-2,9-diazaheptacyclo[...)
Affinity DataIC50: 3nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50061977(CHEMBL117908 | 17,25-diazonia-2,9-diazaheptacyclo[...)
Affinity DataIC50: 3nMAssay Description:Inhibition of hSK1 calcium activated potassium channel (SKCa channel)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50061977(CHEMBL117908 | 17,25-diazonia-2,9-diazaheptacyclo[...)
Affinity DataIC50: 3nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50263327(N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
LigandPNGBDBM50474856(CHEMBL184300)
Affinity DataIC50: 9nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50474870(CHEMBL185146)
Affinity DataIC50: 10nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50474869(CHEMBL181911)
Affinity DataIC50: 12nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50474865(CHEMBL183644)
Affinity DataIC50: 15nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50474867(CHEMBL184858)
Affinity DataIC50: 16nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50476799(CHEMBL397282)
Affinity DataKi:  23nMAssay Description:Displacement of [125I]apamin from SK channel in Wistar rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandPNGBDBM50474866(CHEMBL181912)
Affinity DataIC50: 25nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50473100(CHEMBL344807)
Affinity DataIC50: 25nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50473103(CHEMBL430146)
Affinity DataIC50: 28nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50473103(CHEMBL430146)
Affinity DataIC50: 28nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50474868(CHEMBL184891)
Affinity DataIC50: 30nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50474871(CHEMBL182716)
Affinity DataIC50: 31nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50476809(CHEMBL394773)
Affinity DataKi:  33nMAssay Description:Displacement of [125I]apamin from SK channel in Wistar rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandPNGBDBM50476802(CHEMBL395568)
Affinity DataKi:  35nMAssay Description:Displacement of [125I]apamin from SK channel in Wistar rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandPNGBDBM50474863(CHEMBL360624)
Affinity DataIC50: 35nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50474872(CHEMBL1180184)
Affinity DataIC50: 40nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50476800(CHEMBL242790)
Affinity DataKi:  42nMAssay Description:Displacement of [125I]apamin from SK channel in Wistar rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandPNGBDBM50264020(TCMDC-124275 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Affinity DataIC50: 43nMAssay Description:Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
LigandPNGBDBM50275090((1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetr...)
Affinity DataKd:  54nMAssay Description:Inhibition of human SK1 channel by inside-out patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50473097(CHEMBL136488)
Affinity DataIC50: 60nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50474858(CHEMBL186139)
Affinity DataIC50: 60nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50150389(17,23-diazonia-2,9-diazahexacyclo[21.6.2.24,7.210,...)
Affinity DataIC50: 60nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50474859(CHEMBL185258)
Affinity DataIC50: 65nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50473106(CHEMBL137175)
Affinity DataIC50: 70nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50473106(CHEMBL137175)
Affinity DataIC50: 70nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50084848(BIs-cyclo(4N-pentyl-1-(4-methylbenzyl)-4-quinolini...)
Affinity DataIC50: 80nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50473094(CHEMBL137155)
Affinity DataIC50: 90nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50476798(CHEMBL242789)
Affinity DataKi:  90nMAssay Description:Displacement of [125I]apamin from SK channel in Wistar rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandPNGBDBM50473098(CHEMBL342213)
Affinity DataIC50: 100nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50476801(CHEMBL241952)
Affinity DataKi:  106nMAssay Description:Displacement of [125I]apamin from SK channel in Wistar rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandPNGBDBM50084852(4N-[10-(1-methyl-4-quinoliniumylamino)decyl]-1-[3-...)
Affinity DataIC50: 110nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50473099(CHEMBL140380)
Affinity DataIC50: 120nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50474857(CHEMBL185106)
Affinity DataIC50: 130nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50473107(CHEMBL341700)
Affinity DataIC50: 130nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50473107(CHEMBL341700)
Affinity DataIC50: 130nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50476807(CHEMBL242791)
Affinity DataKi:  132nMAssay Description:Displacement of [125I]apamin from SK channel in Wistar rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandPNGBDBM50084849(Bis-quinolinium cyclophane analogue | Cyclo(N-deca...)
Affinity DataIC50: 150nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50476803(CHEMBL242579)
Affinity DataKi:  150nMAssay Description:Displacement of [125I]apamin from SK channel in Wistar rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandPNGBDBM50474873(CHEMBL185137)
Affinity DataIC50: 150nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50474862(CHEMBL425707)
Affinity DataIC50: 150nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
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