Compile Data Set for Download or QSAR
Report error Found 4220 Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily A member 1'
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 0.0510nMAssay Description:Antagonist activity at GFP-tagged human TRPA1 transfected in HEK293F cells assessed as reduction in AITC-induced inward current at -60 mV holding pot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50327667(Dibenzo[b,f][1,4]oxazepine-4-carboxylic Acid Methy...)
Affinity DataEC50:  0.0603nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 0.0670nMAssay Description:Antagonist activity at recombinant human TRPA1 expressed in HEK293F cells assessed as reduction in AITC-induced increase in intracellular Ca2+ level ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50327675(Dibenzo[b,f][1,4]oxazepine-4-carboxylic Acid Amide...)
Affinity DataEC50:  0.0759nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50327675(Dibenzo[b,f][1,4]oxazepine-4-carboxylic Acid Amide...)
Affinity DataEC50:  0.0800nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50327673(Dibenzo[b,f][1,4]oxazepine-6-carbonitrile | CHEMBL...)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50327658(11H-Dibenzo[b,e]-azepine-10-carboxylic Acid Methyl...)
Affinity DataEC50:  0.100nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 0.101nMAssay Description:Antagonist activity at GFP-tagged rat TRPA1 transfected in HEK293F cells assessed as reduction in AITC-induced inward current at -60 mV holding poten...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50327676(Dibenzo[b,f][1,4]oxazepine-6-carboxylic acid amide...)
Affinity DataEC50:  0.110nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50327676(Dibenzo[b,f][1,4]oxazepine-6-carboxylic acid amide...)
Affinity DataEC50:  0.115nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50415923(CHEMBL1084098)
Affinity DataEC50:  0.117nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50327672(Dibenzo[b,f][1,4]oxazepine-4-carbonitrile | CHEMBL...)
Affinity DataEC50:  0.150nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 0.289nMAssay Description:Antagonist activity at rat TRPA1 expressed in HEK293F cells assessed as reduction in AITC-induced increase in intracellular Ca2+ level by FLIPR-based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 0.296nMAssay Description:Antagonist activity at mouse TRPA1 expressed in HEK293F cells assessed as reduction in AITC-induced increase in intracellular Ca2+ level by FLIPR-bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM452629(7-bromo-5-methyl-3-[[3- [rac-(3R,5R)-5-(4- chlorop...)
Affinity DataIC50: 0.300nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

LigandPNGBDBM50318511(dibenzo[b,f][1,4]oxazepine | CHEMBL1085100)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50318511(dibenzo[b,f][1,4]oxazepine | CHEMBL1085100)
Affinity DataEC50:  0.302nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM611197((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[3-[5...)
Affinity DataIC50: 0.380nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

LigandPNGBDBM50327661(11H-dibenzo[b,e]azepine-2-carboxylic acid methyl e...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM611196((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[3-[6...)
Affinity DataIC50: 0.410nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

LigandPNGBDBM452561(5-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50: 0.420nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

LigandPNGBDBM611264((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[3-[4...)
Affinity DataIC50: 0.480nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

LigandPNGBDBM50327661(11H-dibenzo[b,e]azepine-2-carboxylic acid methyl e...)
Affinity DataEC50:  0.575nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50327660(11H-Dibenzo[b,e]azepine-1-carboxylic acid methyl e...)
Affinity DataEC50:  0.575nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50327660(11H-Dibenzo[b,e]azepine-1-carboxylic acid methyl e...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM611236((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[2-[4...)
Affinity DataIC50: 0.610nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

LigandPNGBDBM611235((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[2-[4...)
Affinity DataIC50: 0.610nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

LigandPNGBDBM50650150(CHEMBL4516422)
Affinity DataEC50:  0.650nMAssay Description:Agonist activity at TRPA1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM452526(2-amino-3-((3-((3R,5R)- 5-(4- chlorophenyl)tetrahy...)
Affinity DataIC50: 0.660nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

LigandPNGBDBM611331((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[6-[6...)
Affinity DataIC50: 0.660nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

LigandPNGBDBM452576(US10710994, Example 54 | 3-((3-((3R,5R)-5-(4- chlo...)
Affinity DataIC50: 0.730nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

LigandPNGBDBM611205((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[2-[4...)
Affinity DataIC50: 0.760nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

LigandPNGBDBM452629(7-bromo-5-methyl-3-[[3- [rac-(3R,5R)-5-(4- chlorop...)
Affinity DataIC50: 0.800nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

LigandPNGBDBM452570(3-((3-((3R,5R)-5-(4- chlorophenyl)tetra- hydrofura...)
Affinity DataIC50: 0.800nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

LigandPNGBDBM611240((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[2-[6...)
Affinity DataIC50: 0.830nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

LigandPNGBDBM611265((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[3-[4...)
Affinity DataIC50: 0.830nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

LigandPNGBDBM611198((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[6-[4...)
Affinity DataIC50: 0.840nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

LigandPNGBDBM452523(US10710994, Example 1 | US10710994, Example 5 | US...)
Affinity DataIC50: 0.880nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

LigandPNGBDBM611330((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[4-[5...)
Affinity DataIC50: 0.880nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

LigandPNGBDBM50327657(2-chlorobenzylidenemalononitrile | CHEMBL1256101)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM611245((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[2-[2...)
Affinity DataIC50: 0.970nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

LigandPNGBDBM361656(US10221177, Compound 19)
Affinity DataIC50: 1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

LigandPNGBDBM361663(US10221177, Compound 26)
Affinity DataIC50: 1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

LigandPNGBDBM361651(US10221177, Compound 270 | US10221177, Compound 14)
Affinity DataIC50: 1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

LigandPNGBDBM361655(US10221177, Compound 18)
Affinity DataIC50: 1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

LigandPNGBDBM361717(US10221177, Compound 80)
Affinity DataIC50: 1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

LigandPNGBDBM361736(US10221177, Compound 99)
Affinity DataIC50: 1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

LigandPNGBDBM361868(US10221177, Compound 241)
Affinity DataIC50: 1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

LigandPNGBDBM361666(US10221177, Compound 29)
Affinity DataIC50: 1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

LigandPNGBDBM361792(US10221177, Compound 157)
Affinity DataIC50: 1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

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