Report error Found 132 Enz. Inhib. hit(s) with Target = 'Ubiquitin carboxyl-terminal hydrolase 5'
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 9.90nMAssay Description:Binding affinity to human USP5 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of full length USP5 (1 to 835 residues) (unknown origin) expressed in Escherichia coli using DU48-03 as substrate preincubated with enzyme...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 2.80E+3nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of USP5 in human Z138 cells after 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 3.10E+3nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 3.40E+3nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli incub...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKi: 4.00E+3nMAssay Description:Inhibition of wild type human USP5 expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 4.50E+3nMAssay Description:Binding affinity to N-terminal Avi-tagged and C-terminal His6-tagged USP5 (171 to 290 residues) (unknown origin) expressed in Escherichia coli BirA a...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of wild type human USP5 expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 6.30E+3nMAssay Description:Binding affinity to N-terminal Avi-tagged and C-terminal His6-tagged USP5 (171 to 290 residues) (unknown origin) expressed in Escherichia coli BirA a...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Displacement of N-terminal FITC-labeled Ub from biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) express...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 7.00E+3nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 7.00E+3nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Antagonist activity at USP5 (1 to 835 residues) (unknown origin) assessed as deubiquitinase activity using ubiquitin-rhodamine110 as substrate and me...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 8.00E+3nMAssay Description:Binding affinity to full length biotinylated USP5 (1 to 835 residues) (unknown origin) expressed in Escherichia coli by surface plasmon resonance ass...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 8.00E+3nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataEC50: 8.60E+3nMAssay Description:Inhibition of USP5 (unknown origin)More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 9.00E+3nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 9.00E+3nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 6His-tagged USP5 expressed in Escherichia coli assessed as cleavage of Ubiquitin-Rhodamine110-glycine to Ubiquitin and Rhodamine1...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 1.20E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKi: 1.25E+4nMAssay Description:Competitive inhibition of wild type human USP5 expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrateMore data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 1.30E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 1.60E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 1.80E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 1.90E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 2.10E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 2.10E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataIC50: 2.15E+4nMAssay Description:Inhibition of human USP5 using Ub-PA as substrate assessed as deubiquitination level incubated for 1 hr by SDS-PAGE assayMore data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 2.20E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 2.20E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 2.30E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 2.50E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of full length USP5 (1 to 835 residues) (unknown origin) expressed in Escherichia coli using DU48-02 as substrate preincubated with enzyme...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataIC50: 2.91E+4nMAssay Description:Inhibition of human USP5 using Ub-PA as substrate assessed as deubiquitination level incubated for 1 hr by SDS-PAGE assayMore data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 3.10E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 3.10E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 3.30E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 3.40E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 3.40E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 3.80E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 3.90E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 4.00E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 4.20E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 4.50E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataIC50: 4.60E+4nMAssay Description:Displacement of N-terminal FITC-labeled Ub from full length biotinylated USP5 (unknown origin) expressed in Escherichia coli incubated for 1 hr by fl...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 4.70E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 5.20E+4nMAssay Description:Binding affinity to N-terminal Avitag-fused His6-tagged USP5 ZnF-UBD (unknown origin) (171 to 290 residues) labelled with 5-fluorotryptophan expresse...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 5.20E+4nMAssay Description:Binding affinity to N-terminal Avitag-fused His6-tagged USP5 ZnF-UBD (unknown origin) (171 to 290 residues) labelled with 5-fluorotryptophan expresse...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 5(Human)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 5.40E+4nMAssay Description:Binding affinity to biotinylated USP5 zinc finger ubiquitin binding domain (171 to 290 residues) (unknown origin) expressed in Escherichia coli by su...More data for this Ligand-Target Pair


3D Structure (crystal)




































