Report error Found 15680 Enz. Inhib. hit(s) with Target = 'Vascular endothelial growth factor receptor 2'
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of VEGFR-2 (unknown origin) expressed in PAE cells assessed as reduction in VEGFA induced protein phosphorylation preincubated for 1 hr fo...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataKi: 0.0210nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 60 mins by activity based 100 fold dilution assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0230nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataKi: 0.0240nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 60 mins by activity based 100 fold dilution assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0330nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 preincubated for 120 mins in presence of ATP by AlphaScreen analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of recombinant human full length KDR using poly(Glu, Tyr) as substrate by alphascreen assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataKi: 0.0350nMAssay Description:Compounds 2-4 and cabozantinib were each tested for binding of c-Met, VEGFR2, TIE2 and the control compound, staurosporine. Specifically, each compou...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of recombinant human full length VEGFR2 using poly (Glu, Tyr) as substrate by alpha screen assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of human recombinant full length VEGFR2 using poly (Glu,Tyr) as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of human VEGFR-2 using poly(Glu, Tyr) as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of VEGFR2 phosphorylation (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of human recombinant full length VEGFR2 in presence of ATP by alphascreen assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of full length recombinant human GST or His-tagged VEGFR2 using poly (Glu, Tyr) as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataKi: 0.0440nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 60 mins by ligand displacement based enzyme-inhibitor dilution assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ULight-4E-BP1 peptide as substrate incubated for 1 hr in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0620nMAssay Description:Inhibition of human vascular endothelial growth factor receptor 2 (VEGFR-2)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0860nMAssay Description:Inhibition of VEGFR-2 (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0930nMAssay Description:Inhibition of VEGFR2 (unknown origin) using biotinylated poly(Glu:Tyr) as substrate after 60 mins by AlphaScreen assay in presence of 1000 uM of ATPMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly-(Glu,Tyr 4:1) peptide as substrate incubated for 1 hr by ELISA methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.110nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataKi: 0.120nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 60 mins by ligand displacement based enzyme-inhibitor dilution assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.120nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ULight-4E-BP1 peptide as substrate incubated for 1 hr in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataKd: 0.130nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataKi: 0.130nMAssay Description:Inhibition of human recombinant His-tagged VEGFR2 assessed as infrared absorptionMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.140nMAssay Description:Inhibition of VEGFR-2 (unknown origin) after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.150nMAssay Description:Inhibition of VEGFR-2 (unknown origin) after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.160nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 preincubated for 120 mins in presence of ATP by AlphaScreen analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.160nMAssay Description:Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataKi: 0.160nMAssay Description:Inhibition of VEGFR2 by [32P]ATP-competitive radioassayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.160nMAssay Description:Inhibition of VEGFR-2 phosphorylation in serum starved human HUVEC cells incubated for 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.160nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.170nMAssay Description:Inhibition of VEGFR2 (unknown origin) after 1 hr by ADP-Glo reagent based luminescent assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.170nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.170nMAssay Description:Inhibition of VEGFR-2 (unknown origin) after 1 hrs by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataKi: 0.170nMAssay Description:Inhibition of VEGFR2 by [32P]ATP-competitive radioassayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.180nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.190nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.190nMAssay Description:Inhibition of VEGFR2 (unknown origin) using biotinylated poly(Glu:Tyr) as substrate after 60 mins by AlphaScreen assay in presence of 1000 uM of ATPMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.190nMAssay Description:Inhibition of VEGFR-2 (unknown origin) kinase activity using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

3D Structure (crystal)




















