Compile Data Set for Download or QSAR
Report error Found 155 Enz. Inhib. hit(s) with Target = 'cAMP-dependent protein kinase catalytic subunit PRKX'
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human PRKX using LRRASLG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human PRKX using LRRASLG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human PRKX using LRRASLG as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by radi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM687757(US20240246972, Compound 4 | Synthesis of N-(1-(2-f...)
Affinity DataIC50: 6.60nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)
Affinity DataKd:  7.20nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM687755(US20240246972, Compound 2 | Synthesis of N-(2-fluo...)
Affinity DataIC50: 7.80nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  13nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  13nMAssay Description:Binding constant for full-length PRKXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM687769(US20240246972, Compound 10 | Synthesis of N-{[2-(f...)
Affinity DataIC50: 27.3nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM687767(US20240246972, Compound 7 | Synthesis of N-(1-(3-(...)
Affinity DataIC50: 28.2nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM687754(US20240246972, Compound 1 | Synthesis of N-(2-fluo...)
Affinity DataIC50: 31.4nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM687759(US20240246972, Compound 6 | Synthesis of N-(2-chlo...)
Affinity DataIC50: 32.3nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  42nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  42nMAssay Description:Binding affinity to PRKXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  43nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged PRKX (unknown origin) expressed in baculovirus infected Sf9 insect cells i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM687764(US20240246972, Comparator 4)
Affinity DataIC50: 62nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM687762(US20240246972, Comparator 2)
Affinity DataIC50: 73nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50417843(CHEMBL1667967)
Affinity DataIC50: 79.4nMAssay Description:Inhibition of human PrkX by RFBA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM15138(Biochemistry 469551 Compound 11 | 5-indazolyl pyri...)
Affinity DataKd:  97nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50358480(CHEMBL1922132 | US20240246972, Comparator 6)
Affinity DataIC50: 165nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50358485(CHEMBL1923172 | US20240246972, Comparator 7)
Affinity DataIC50: 222nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 326nMAssay Description:Inhibition of wild-type human partial length PRKX (M1 to F358 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM687763(US20240246972, Comparator 3)
Affinity DataIC50: 376nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM687756(US20240246972, Compound 3 | Synthesis of N-(1-(3-m...)
Affinity DataIC50: 396nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50429615(CHEMBL2334586)
Affinity DataIC50: 580nMAssay Description:Inhibition of human wild type partial length PRKX (M1 to F358 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM687758(US20240246972, Compound 5 | Synthesis of N-(1-(3-m...)
Affinity DataIC50: 614nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  960nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  960nMAssay Description:Binding affinity to PRKXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  960nMAssay Description:Binding constant for full-length PRKXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50462709(CHEMBL4245507)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PRKX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM174948(US9096593, P-2049)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PRKX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PRKX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human wild type PRKX using RBER-GSK3(14 to 27) as substrate preincubated for 2 hrs followed by ATP addition and measured every 2 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM687776(US20240246972, Comparator 8)
Affinity DataIC50: 1.00E+3nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  1.20E+3nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.49E+3nMAssay Description:Inhibition of PRKXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM687765(US20240246972, Comparator 5)
Affinity DataIC50: 1.56E+3nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM687761(US20240246972, Comparator 1)
Affinity DataIC50: 3.40E+3nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  4.40E+3nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  5.80E+3nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50417844(CHEMBL1667963)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of human PrkX by RFBA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM15244(cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM12621(2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50499634(CHEMBL3741589)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRKX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50355504(CHEMBL1908393)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
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