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Found 97 with Last Name = 'hasegawa' and Initial = 'f'
TargetGlucagon receptor(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50122102(3-Cyano-4-hydroxy-benzoic acid [1-(2,3,5,6-tetrame...)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity against human glucagon receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057796(CHEMBL3326188)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of glucagon-induced glucagon receptor-mediated cAMP production in rat hepatocytes after 15 mins by cAMP dynamic2 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057824(CHEMBL3326175)
Affinity DataIC50:  87nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057820(CHEMBL3326174)
Affinity DataIC50:  160nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057813(CHEMBL3326173)
Affinity DataIC50:  270nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057796(CHEMBL3326188)
Affinity DataIC50:  292nMAssay Description:Inhibition of glucagon-induced glucagon receptor-mediated cAMP production in human hepatocytes after 15 mins by cAMP dynamic2 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057806(CHEMBL3326172)
Affinity DataIC50:  430nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057798(CHEMBL3326170)
Affinity DataIC50:  970nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057796(CHEMBL3326188)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057796(CHEMBL3326188)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of GLP-1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057800(CHEMBL3326171)
Affinity DataIC50:  1.40E+3nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057864(CHEMBL3325456)
Affinity DataIC50:  2.90E+3nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057817(CHEMBL3326187)
Affinity DataIC50:  5.50E+3nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057797(CHEMBL3326165)
Affinity DataIC50:  9.50E+3nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057825(CHEMBL3326176)
Affinity DataIC50:  9.50E+3nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057796(CHEMBL3326188)
Affinity DataIC50:  9.60E+3nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057831(CHEMBL3326177)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM307520((S)-2-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6...)
Affinity DataIC50: >1.00E+4nMAssay Description:The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM307521(2-((4-((2-amino-4-(butylamino)-6-methylpyrimidin-5...)
Affinity DataIC50: >1.00E+4nMAssay Description:The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM307522((S)-2-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6...)
Affinity DataIC50: >1.00E+4nMAssay Description:The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM307523((S)-2-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6...)
Affinity DataIC50: >1.00E+4nMAssay Description:The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM307524((S)-3-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6...)
Affinity DataIC50: >1.00E+4nMAssay Description:The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM307525((S)-3-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6...)
Affinity DataIC50: >1.00E+4nMAssay Description:The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM307526((S)-2-(N-(4-((2-amino-4-(1-hydroxyhexan-3-ylamino)...)
Affinity DataIC50: >1.00E+4nMAssay Description:The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM307527((R)-1-(3-(4-((2-amino-4-((S)-1-hydroxyhexan-3-ylam...)
Affinity DataIC50: >1.00E+4nMAssay Description:The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM307528((S)-1-(3-(4-((2-amino-4-((S)-1-hydroxyhexan-3-ylam...)
Affinity DataIC50: >1.00E+4nMAssay Description:The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50058003(CHEMBL3326186)
Affinity DataIC50:  2.40E+4nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057859(CHEMBL3326181)
Affinity DataIC50:  2.70E+4nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM307524((S)-3-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6...)
Affinity DataIC50: >3.30E+4nMAssay Description:Cell CultureThe hERG-expressing Chinese hamster ovary K1 (CHO) cells described by (Persson, Carlsson, Duker, & Jacobson, 2005) were grown to semi-con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM307522((S)-2-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6...)
Affinity DataIC50: >3.30E+4nMAssay Description:Cell CultureThe hERG-expressing Chinese hamster ovary K1 (CHO) cells described by (Persson, Carlsson, Duker, & Jacobson, 2005) were grown to semi-con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM307520((S)-2-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6...)
Affinity DataIC50: >3.30E+4nMAssay Description:Cell CultureThe hERG-expressing Chinese hamster ovary K1 (CHO) cells described by (Persson, Carlsson, Duker, & Jacobson, 2005) were grown to semi-con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM307525((S)-3-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6...)
Affinity DataIC50: >3.30E+4nMAssay Description:Cell CultureThe hERG-expressing Chinese hamster ovary K1 (CHO) cells described by (Persson, Carlsson, Duker, & Jacobson, 2005) were grown to semi-con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057863(CHEMBL3326185)
Affinity DataIC50:  4.40E+4nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057861(CHEMBL3326183)
Affinity DataIC50:  6.90E+4nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Osaka University

Curated by ChEMBL
LigandPNGBDBM50260354(CHEMBL4082465)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of human full length recombinant PDE4A1A using FAM-cAMP as substrate after 30 mins by fluorescence based spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Osaka University

Curated by ChEMBL
LigandPNGBDBM50260354(CHEMBL4082465)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of human full length recombinant PDE4A1A using FAM-cAMP as substrate after 30 mins by fluorescence based spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057834(CHEMBL3326178)
Affinity DataIC50:  8.90E+4nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057860(CHEMBL3326182)
Affinity DataIC50:  9.30E+4nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057849(CHEMBL3326180)
Affinity DataIC50:  1.00E+5nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057836(CHEMBL3326179)
Affinity DataIC50:  1.80E+5nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Rattus norvegicus)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50057862(CHEMBL3326184)
Affinity DataIC50:  2.70E+5nMAssay Description:Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM307520((S)-2-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6...)
Affinity DataEC50:  6.80E+3nMAssay Description:Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM307521(2-((4-((2-amino-4-(butylamino)-6-methylpyrimidin-5...)
Affinity DataEC50:  6.10E+3nMAssay Description:Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM307522((S)-2-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6...)
Affinity DataEC50:  7.10E+3nMAssay Description:Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM307523((S)-2-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6...)
Affinity DataEC50:  7.00E+3nMAssay Description:Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM307524((S)-3-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6...)
Affinity DataEC50:  7.30E+3nMAssay Description:Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM307525((S)-3-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6...)
Affinity DataEC50:  6.60E+3nMAssay Description:Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM307526((S)-2-(N-(4-((2-amino-4-(1-hydroxyhexan-3-ylamino)...)
Affinity DataEC50:  6.60E+3nMAssay Description:Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM307527((R)-1-(3-(4-((2-amino-4-((S)-1-hydroxyhexan-3-ylam...)
Affinity DataEC50:  6.90E+3nMAssay Description:Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM307528((S)-1-(3-(4-((2-amino-4-((S)-1-hydroxyhexan-3-ylam...)
Affinity DataEC50:  6.70E+3nMAssay Description:Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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