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Found 43 with Last Name = 'xie' and Initial = 'g'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391086(CHEMBL2087358)
Affinity DataIC50:  2nMAssay Description:Inhibition of EGFR using GST-Crk as substrate assessed as phosphorylated Crk level after 20 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391088(CHEMBL2087360)
Affinity DataIC50:  2nMAssay Description:Inhibition of EGFR using GST-Crk as substrate assessed as phosphorylated Crk level after 20 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391089(BPI-2009 | CHEMBL2087361 | Conmana | Icotinib | Lc...)
Affinity DataIC50:  2nMAssay Description:Inhibition of EGFR using GST-Crk as substrate assessed as phosphorylated Crk level after 20 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Beta Pharma

US Patent
LigandPNGBDBM186015(US9163010, Formula II)
Affinity DataIC50:  2.5nMAssay Description:The effects of compound of formula II on inhibiting VEGFR were compared against that of sunitinib in vitro.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391084(CHEMBL2087355)
Affinity DataIC50:  5nMAssay Description:Inhibition of EGFR using GST-Crk as substrate assessed as phosphorylated Crk level after 20 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391090(CHEMBL2087356)
Affinity DataIC50:  5nMAssay Description:Inhibition of EGFR using GST-Crk as substrate assessed as phosphorylated Crk level after 20 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391085(CHEMBL2087357)
Affinity DataIC50:  7nMAssay Description:Inhibition of EGFR using GST-Crk as substrate assessed as phosphorylated Crk level after 20 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391087(CHEMBL2087359)
Affinity DataIC50:  8nMAssay Description:Inhibition of EGFR using GST-Crk as substrate assessed as phosphorylated Crk level after 20 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM2683(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Beta Pharma

US Patent
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  10nMAssay Description:The effects of compound of formula II on inhibiting VEGFR were compared against that of sunitinib in vitro.More data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50:  20nMAssay Description:Inhibition of smoothened (unknown origin)-mediated Shh signalingMore data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50:  33nMAssay Description:Antagonist activity at smoothened (unknown origin) expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibiti...More data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50449053(CHEMBL3126707)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at smoothened (unknown origin) expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibiti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Beta Pharma

US Patent
LigandPNGBDBM186015(US9163010, Formula II)
Affinity DataIC50:  40nMAssay Description:The effects of compound of formula II on inhibiting VEGFR were compared against that of sunitinib in vitro.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391089(BPI-2009 | CHEMBL2087361 | Conmana | Icotinib | Lc...)
Affinity DataIC50:  45nMAssay Description:Inhibition of EGFR-mediated intracellular tyrosine phosphorylation in EGF-stimulated human A431 cells after 2.5 hrs by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391088(CHEMBL2087360)
Affinity DataIC50:  45nMAssay Description:Inhibition of EGFR-mediated intracellular tyrosine phosphorylation in EGF-stimulated human A431 cells after 2.5 hrs by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391084(CHEMBL2087355)
Affinity DataIC50:  50nMAssay Description:Inhibition of EGFR-mediated intracellular tyrosine phosphorylation in EGF-stimulated human A431 cells after 2.5 hrs by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391090(CHEMBL2087356)
Affinity DataIC50:  50nMAssay Description:Inhibition of EGFR-mediated intracellular tyrosine phosphorylation in EGF-stimulated human A431 cells after 2.5 hrs by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391082(CHEMBL2087353)
Affinity DataIC50:  55nMAssay Description:Inhibition of EGFR using GST-Crk as substrate assessed as phosphorylated Crk level after 20 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391086(CHEMBL2087358)
Affinity DataIC50:  55nMAssay Description:Inhibition of EGFR-mediated intracellular tyrosine phosphorylation in EGF-stimulated human A431 cells after 2.5 hrs by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391080(CHEMBL1198361)
Affinity DataIC50:  85nMAssay Description:Inhibition of EGFR using GST-Crk as substrate assessed as phosphorylated Crk level after 20 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50449054(CHEMBL3126705)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at smoothened (unknown origin) expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibiti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391081(CHEMBL2087352)
Affinity DataIC50:  120nMAssay Description:Inhibition of EGFR using GST-Crk as substrate assessed as phosphorylated Crk level after 20 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391083(CHEMBL2087354)
Affinity DataIC50:  150nMAssay Description:Inhibition of EGFR using GST-Crk as substrate assessed as phosphorylated Crk level after 20 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286555(4-({4-[4-(2-{3-[4-(1H-Indol-3-yl)-2,5-dioxo-2,5-di...)
Affinity DataIC50:  170nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286557(4-{[4-(2-{3-[4-(1H-Indol-3-yl)-2,5-dioxo-2,5-dihyd...)
Affinity DataIC50:  280nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSmoothened homolog(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50449052(CHEMBL3126692)
Affinity DataIC50:  300nMAssay Description:Antagonist activity at smoothened (unknown origin) expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibiti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286554(2N-[5-(3-dimethylaminopropylcarbamoyl)-1-methyl-1H...)
Affinity DataIC50:  460nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286559(4-(2-{3-[4-(1H-Indol-3-yl)-2,5-dioxo-2,5-dihydro-1...)
Affinity DataIC50:  500nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286558(2N-(3-dimethylaminopropyl)-4-(4-{3-[4-(1H-3-indoly...)
Affinity DataIC50:  630nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286556(4-(2-{3-[4-(1H-Indol-3-yl)-2,5-dioxo-2,5-dihydro-1...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391087(CHEMBL2087359)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of EGFR-mediated intracellular tyrosine phosphorylation in EGF-stimulated human A431 cells after 2.5 hrs by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang Betapharma

Curated by ChEMBL
LigandPNGBDBM50391085(CHEMBL2087357)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of EGFR-mediated intracellular tyrosine phosphorylation in EGF-stimulated human A431 cells after 2.5 hrs by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Nanchang University

Curated by ChEMBL
LigandPNGBDBM50574764(CHEMBL4867070)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant PTP1B catalytic domain (unknown origin) assessed as reduction in pNP formation using pNPP as substrate by absorbance based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Nanchang University

Curated by ChEMBL
LigandPNGBDBM50574763(CHEMBL4866869)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of recombinant PTP1B catalytic domain (unknown origin) assessed as reduction in pNP formation using pNPP as substrate by absorbance based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Nanchang University

Curated by ChEMBL
LigandPNGBDBM50346601(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of recombinant PTP1B catalytic domain (unknown origin) assessed as reduction in pNP formation using pNPP as substrate by absorbance based ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Nanchang University

Curated by ChEMBL
LigandPNGBDBM50574767(CHEMBL4862506)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of recombinant PTP1B catalytic domain (unknown origin) assessed as reduction in pNP formation using pNPP as substrate by absorbance based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Nanchang University

Curated by ChEMBL
LigandPNGBDBM50574766(CHEMBL4861866)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of recombinant PTP1B catalytic domain (unknown origin) assessed as reduction in pNP formation using pNPP as substrate by absorbance based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Nanchang University

Curated by ChEMBL
LigandPNGBDBM50381284(CHEMBL2018876)
Affinity DataIC50:  1.02E+4nMAssay Description:Inhibition of recombinant PTP1B catalytic domain (unknown origin) assessed as reduction in pNP formation using pNPP as substrate by absorbance based ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Nanchang University

Curated by ChEMBL
LigandPNGBDBM50574765(CHEMBL4872765)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of recombinant PTP1B catalytic domain (unknown origin) assessed as reduction in pNP formation using pNPP as substrate by absorbance based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Nanchang University

Curated by ChEMBL
LigandPNGBDBM50193718(2-(2,4-dihydroxy-phenyl)-5-hydroxy-8,8-dimethyl-3-...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of recombinant PTP1B catalytic domain (unknown origin) assessed as reduction in pNP formation using pNPP as substrate by absorbance based ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Nanchang University

Curated by ChEMBL
LigandPNGBDBM50242014(CHEMBL464006 | Morusin | Morusin, 3 | TCMDC-124149...)
Affinity DataIC50:  2.21E+4nMAssay Description:Inhibition of recombinant PTP1B catalytic domain (unknown origin) assessed as reduction in pNP formation using pNPP as substrate by absorbance based ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed